PMID: 8601733Feb 1, 1996Paper

Spontaneous architectural organization of mammalian epidermis from random cell packing

The Journal of Investigative Dermatology
H HondaS Imayama

Abstract

The cells of the stratum corneum in the epidermis of some mammalian species are precisely stacked in columns in a honeycomb fashion. The epidermis constantly loses surface cells, which are replaced by basal cells that have differentiated during migration to the surface. The path of this migration is seen as precisely defined columns of cells that are in compressed Kelvin's tetrakaidecahedral form. We present a computer simulation of this architectural organization based on the assumption that the cells that migrate upward occupy less crowded regions. The simulation not only explained the mechanism by which the architecture is maintained during the process of cell replacement, but also showed that the architecture was spontaneously organized from initial cells supplied at random. Living organisms consist of self-organizing systems at various levels; however, self-organizing systems have been investigated mostly at the molecular level. The present computer simulation clarified the self-organizing system at the cellular level.

Citations

Aug 12, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Lee SilverGianluca Gallo
Nov 13, 2012·PloS One·Benedicte Mengel PersMogens H Jensen
Sep 20, 2007·Theoretical Biology & Medical Modelling·Mathieu Emily, Olivier François
Jul 19, 2018·Experimental Dermatology·Mariko Yokouchi, Akiharu Kubo
Jun 8, 2012·International Journal of Radiation Biology·Amit Roshan, Philip H Jones
May 28, 2016·Science·Panteleimon RompolasValentina Greco
Mar 31, 2015·The EMBO Journal·Agnieszka Wabik, Philip H Jones
May 24, 2011·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·A Hočevar, P Ziherl
Oct 4, 2012·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Sagar ChakrabortySzabolcs Semsey

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