PMID: 3770143Oct 1, 1986Paper

Spontaneous arterial lesions involving breaks in the internal elastic lamina in the rat: effects of beta-aminopropionitrile and familial distribution

Experimental and Molecular Pathology
Mary Osborne-Pellegrin

Abstract

We have studied the effects of beta-aminopropionitrile (BAPN) administration on the formation of spontaneous arterial lesions, characterized principally by a rupture in the internal elastic lamina (IEL) in the caudal and renal arteries of the Wistar rat. Treatment with BAPN (an inhibitor of lysyl oxidase) increased the formation of these lesions in rats up to 12 weeks of age but had differential effects on the caudal and renal artery in older rats. Administration of the nitrile to weanling rats led to the premature formation of lesions in caudal arteries of both male and female rats which morphologically resemble lesions which form spontaneously later in life. Dietary supplements of copper or pyridoxine were without effect on the formation of spontaneous caudal artery lesions when given from 5 wks of age but a copper supplement from midgestation slightly inhibited lesion formation only in male rats. This suggests that if copper deficiency is involved in spontaneous lesion formation, it is only a contributory factor. Quantification of either caudal or renal artery lesions within different litters of Wistar rats showed that there exists a familial aggregation in the frequency of spontaneous lesion formation, certain litters showi...Continue Reading

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Citations

Jun 30, 2011·Indian Journal of Plastic Surgery : Official Publication of the Association of Plastic Surgeons of India·Sreenivasulu ReddyKeerthana Prasad
Oct 7, 2011·Urology Annals·Sreenivasulu ReddyKeerthana Prasad
Feb 12, 2009·Journal of Anatomy·Shaun L SandowRobert M K W Lee
Nov 1, 1990·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·M J Osborne-PellegrinW Hornebeck
May 1, 1997·Stroke; a Journal of Cerebral Circulation·M Coutard, M Osborne-Pellegrin
Apr 1, 1991·Stroke; a Journal of Cerebral Circulation·M Coutard, M Osborne-Pellegrin
May 3, 2014·Physiological Genomics·Samreen FalakMary Osborne-Pellegrin
Feb 1, 1992·Experimental and Molecular Pathology·M J Osborne-Pellegrin, D Fau
Nov 3, 2021·Annals of Biomedical Engineering·Matthew I ConverseKenneth L Monson

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