"Spontaneous" B cell activation due to loss of normal mouse serum suppressor

Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.

"Spontaneous" B cell activation due to loss of normal mouse serum suppressor

Abstract

References

Reversible blocking effect of anti-mouse immunoglobulin serum on the induction of immunity and tolerance in vitro

Mouse myelomas producing precipitating antibody to nucleic acid bases and-or nitrophenyl derivatives

PPD tuberculin--a B-cell mitogen

Immune response suppression by an inhibitor in normal and immune mouse serum

Induction of immunoglobulin and antibody synthesis in vitro by lipopolysaccharides

Identification of direct hemolytic plaques as IgM or IgG plaques by hapten inhibition. Kinetics of anti-hapten plaque forming cell response in the rabbit

Studies on the regulation of avidity at the level of the single antibody-forming cell. The effect of antigen dose and time after immunization

Anti-hapten response in vitro. Affinity differences in precursors of anti-hapten antibody-producing cells

Anti-hapten antibodies in normal sera

Kinetic differences in unresponsiveness of thymus and bone marrow cells

Antitrinitrophenyl (TNP) plaque assay. Primary response of Balb/c mice to soluble and particulate immunogen

In vitro-initiated secondary anti-hapten response. II. Increasing cell avidity for antigen

Immunization of dissociated spleen cell cultures from normal mice

APPLICATION OF A LOCALIZED HEMOLYSIN REACTION FOR SPECIFIC DETECTION OF INDIVIDUAL ANTIBODY-FORMING CELLS

Citations

Genetic basis for unresponsiveness to lipopolysaccharide in C57BL/10Cr mice

Role of the transfer of metabolites from hepatocytes to splenocytes in the suppression of in vitro antibody response by dimethylnitrosamine

Production of DNA single-strand breaks in unstimulated splenocytes by dimethylnitrosamine

Ontogeny of T-cell mitogen response in Lewis rats: I. Culture conditions and developmental patterns

Effects of subchronic exposure to diethylstilbestrol on humoral immune function in adult female (C3B6)F1 mice

Direct suppression of antibody responses by chlorinated dibenzodioxins in cultured spleen cells from (C57BL/6 x C3H)F1 and DBA/2 mice

Elucidation of cellular targets responsible for tetrachlorodibenzo-p-dioxin (TCDD)-induced suppression of antibody responses: II. The role of the T-lymphocyte.

Dependence on intact cells for the in vitro activation of dimethylnitrosamine to an immunosuppressive form

Characterization of the effects of direct alkylators on in vitro immune responses

Inhibition of suppressor cell generation by mouse serum in culture

Immunoglobulin synthesis in vitro by lymphocytes from patients with immune deficiency: requirements for a special serum factor

Influence of dietary restriction on immunologic function and renal disease in (NZB x NZW) F1 mice.

Suppression of the antibody response by a formamidine pesticide: dependence on the route of exposure

Effects of pentachlorophenol on the in vitro and in vivo antibody response

Direct suppression of cultured spleen cell responses by chlordane and the basis for differential effects on in vivo and in vitro immunocompetence

The mitogenic effect of lipopolysaccharide on bone marrow-derived mouse lymphocytes. Lipid A as the mitogenic part of the molecule

The use of bacterial lipopolysaccharides to show that two signals are required for the induction of antibody synthesis

Mechanism of thymus-independent immunocyte triggering. Mitogenic activation of B cells results in specific immune responses

Suppression of the immune response by alpha-fetoprotein on the primary and secondary antibody response

Role of C'3 and Fc receptors in B-lymphocyte activation

The lipoprotein of the outer membrane of Escherichia coli: a B-lymphocyte mitogen

Experimental amyloidosis: the inducer is a polyclonal B-cell activator to which susceptibility is under genetic control

Spleen cells from animals tolerant to a thymus-dependent antigen can be activated by lipopolysaccharide to synthesize antibodies against the tolerogen

Association between mitogenicity and immunogenicity of 4-hydroxy-3,5-dinitrophenacetyl-lipopolysaccharide, a T-independent antigen.

Defective colony formation by B lymphocytes from CBA/N and C3H/HeJ mice

Experimental conditions for obtaining suppressor and helper effects on the primary in vitro immune response by lymphocytes activated by polyclonal T-cell activators

The role of fetal calf serum in the primary immune response in vitro

Frequencies of mitogen-reactive B cells in the mouse. I. Distribution in different lymphoid organs from different inbred strains of mice at different ages

Mitogen-activated B-cell blasts reactive to more than one mitogen.

Role of I-region gene products in macrophage induction of an antibody response. II. Restriction at the level of T cell in recognition of I-J-subregion macrophage determinants

IR gene regulation of the response to trinitrophenyl-polysaccharides. Two independent genes are required for antibody production

Monoclonal antibody characterization of a unique immune response control locus between H-2S and D

Specific and non-specific activation of human and mouse lymphocytes in vitro by pathogenic and apathogenic Neisseria strains

Con-A-activated T cells secrete factors with polyclonal B-cell-activating properties

The continuing carrier problem

The original function of MHC antigens as the general plasma membrane anchorage site of organogenesis-directing proteins

Immune response in the mutant diabetic C57BL/Ks-dt+ mouse. Discrepancies between in vitro and in vivo immunological assays

Impairment of cell-mediated immunity functions by dietary zinc deficiency in mice.

Immunosuppressive effects of 2-acetylaminofluorene and 2-aminofluorene on murine splenocytes culture

B-lymphocyte subpopulations in the mouse. Organ distribution and ontogeny of immunoglobulin-synthesizing and of mitogen-sensitive cells

The role of I region gene products in macrophage - T lymphocyte interaction

Macrophages suppress direct B-cell activation by lipopolysaccharide

Correction: mouse spleen cells cultured in homologous serum can indeed make primary antibodies to sheep erythrocytes

The effect of lipopolysaccharide on the primary immune response to the hapten NNP

Responsiveness of lymphoid precursors to polyclonal B-cell activators

Heterogeneity of B cells: direct evidence of selective triggering of distinct subpopulations by polyclonal activators

Mitogenic properties of polyene antibiotics for murine B cells

Inhibition of in vitro immune responses by a fraction from seminal plasma

Primary antibody response by chicken spleen cells in vitro

The effect of mitomycin C on antigenic and mitogenic stimulation of mouse lymphocytes in vitro

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