Spontaneous baroreflex control of cardiac output during dynamic exercise, muscle metaboreflex activation, and heart failure

American Journal of Physiology. Heart and Circulatory Physiology
Masashi IchinoseFerdinando Iellamo

Abstract

We have previously shown that spontaneous baroreflex-induced changes in heart rate (HR) do not always translate into changes in cardiac output (CO) at rest. We have also shown that heart failure (HF) decreases this linkage between changes in HR and CO. Whether dynamic exercise and muscle metaboreflex activation (via imposed reductions in hindlimb blood flow) further alter this translation in normal and HF conditions is unknown. We examined these questions using conscious, chronically instrumented dogs before and after pacing-induced HF during mild and moderate dynamic exercise with and without muscle metaboreflex activation. We measured left ventricular systolic pressure (LVSP), CO, and HR and analyzed the spontaneous HR-LVSP and CO-LVSP relationships. In normal animals, mild exercise significantly decreased HR-LVSP (-3.08 +/- 0.5 vs. -5.14 +/- 0.6 beats.min(-1).mmHg(-1); P < 0.05) and CO-LVSP (-134.74 +/- 24.5 vs. -208.6 +/- 22.2 ml.min(-1).mmHg(-1); P < 0.05). Moderate exercise further decreased both and, in addition, significantly reduced HR-CO translation (25.9 +/- 2.8% vs. 52.3 +/- 4.2%; P < 0.05). Muscle metaboreflex activation at both workloads decreased HR-LVSP, whereas it had no significant effect on CO-LVSP and the HR...Continue Reading

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Feb 6, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Javier A Sala-MercadoFerdinando Iellamo
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Citations

Nov 10, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Masashi J IchinoseDonal S O'Leary
May 4, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Xiaoxiao ChenDonal S O'Leary
Aug 3, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Masashi IchinoseDonal S O'Leary
May 13, 2014·BioMed Research International·Antonio C L NobregaAntonio Crisafulli
Jul 9, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Masashi IchinoseTakeshi Nishiyasu
May 24, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Masashi IchinoseTakeshi Nishiyasu
Sep 29, 2015·Medicine and Science in Sports and Exercise·Erik H Van ItersonThomas P Olson
Sep 21, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Kazuhito WatanabeTakeshi Nishiyasu
Apr 30, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Joseph MannozziDonal S O'Leary

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