Spontaneous baroreflex control of heart rate versus cardiac output: altered coupling in heart failure

American Journal of Physiology. Heart and Circulatory Physiology
Javier A Sala-MercadoDonal S O'Leary

Abstract

Dynamic cardiac baroreflex responses are frequently investigated by analyzing the spontaneous reciprocal changes in arterial pressure and heart rate (HR). However, whether the spontaneous baroreflex-induced changes in HR translate into changes in cardiac output (CO) is unknown. In addition, this linkage between changes in HR and changes in CO may be different in subjects with heart failure (HF). We examined these questions using conscious dogs before and after pacing-induced HF. Spontaneous baroreflex sensitivity in the control of HR and CO was evaluated as the slopes of the linear relationships between HR or CO and left ventricular systolic pressure (LVSP) during spontaneous sequences of greater or equal to three consecutive beats when HR or CO changed inversely versus pressure. Furthermore, the translation of baroreflex HR responses into CO responses (HR-CO translation) was examined by computing the overlap between HR and CO sequences. In normal resting conditions, 44.0 +/- 4.4% of HR sequences overlapped with CO sequences, suggesting that only around half of the baroreflex HR responses cause CO responses. In HF, HR-LVSP, CO-LVSP, and the HR-CO translation significantly decreased compared with the normal condition (-2.29 +/- ...Continue Reading

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Jun 19, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Jong-Kyung KimDonal S O'Leary
Jul 19, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Ferdinando IellamoMaurizio Volterrani
Dec 26, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Javier A Sala-MercadoDonal S O'Leary
Feb 6, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Javier A Sala-MercadoFerdinando Iellamo
Jul 3, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Ferdinando IellamoDonal S O'Leary

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Citations

Dec 8, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Javier A Sala-MercadoDonal S O'Leary
May 4, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Xiaoxiao ChenDonal S O'Leary
Aug 3, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Masashi IchinoseDonal S O'Leary
Dec 22, 2010·International Heart Journal·Takuya Kishi, Kenji Sunagawa
May 13, 2014·BioMed Research International·Antonio C L NobregaAntonio Crisafulli
Dec 20, 2017·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Simon Gelman, Luca Bigatello
Apr 1, 2020·Journal of the American Heart Association·Arjen MolAndrea B Maier

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