Spontaneous Ca(2+) transients in interstitial cells of Cajal located within the deep muscular plexus of the murine small intestine.

The Journal of Physiology
Salah A BakerKenton M Sanders

Abstract

Interstitial cells of Cajal at the level of the deep muscular plexus (ICC-DMP) in the small intestine generate spontaneous Ca(2+) transients that consist of localized Ca(2+) events and limited propagating Ca(2+) waves. Ca(2+) transients in ICC-DMP display variable characteristics: from discrete, highly localized Ca(2+) transients to regionalized Ca(2+) waves with variable rates of occurrence, amplitude, duration and spatial spread. Ca(2+) transients fired stochastically, with no cellular or multicellular rhythmic activity being observed. No correlation was found between the firing sites in adjacent cells. Ca(2+) transients in ICC-DMP are suppressed by the ongoing release of inhibitory neurotransmitter(s). Functional intracellular Ca(2+) stores are essential for spontaneous Ca(2+) transients, and the sarco/endoplasmic reticulum Ca(2+) -ATPase (SERCA) pump is necessary for maintenance of spontaneity. Ca(2+) release mechanisms involve both ryanodine receptors (RyRs) and inositol triphosphate receptors (InsP3 Rs). Release from these channels is interdependent. ICC express transcripts of multiple RyRs and InsP3 Rs, with Itpr1 and Ryr2 subtypes displaying the highest expression. Interstitial cells of Cajal in the deep muscular plexus...Continue Reading

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Citations

Feb 18, 2017·International Journal of Molecular Sciences·Beatrice Mihaela RaduSanda Maria Cretoiu
Feb 1, 2018·The Journal of Physiology·Bernard T DrummKenton M Sanders
Mar 11, 2017·American Journal of Physiology. Gastrointestinal and Liver Physiology·Brian D Gulbransen
Dec 1, 2017·Nature Reviews. Gastroenterology & Hepatology·Werend BoesmansPieter Vanden Berghe
Feb 14, 2018·Journal of the American Society of Nephrology : JASN·Samir M IskanderNorman D Rosenblum
Dec 10, 2019·American Journal of Physiology. Gastrointestinal and Liver Physiology·Sean P Parsons, Jan D Huizinga
Feb 23, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Masaaki KurahashiKenton M Sanders
Oct 19, 2019·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Caroline A CobineKathleen D Keef
May 18, 2020·The Journal of Physiology·Nathan GraingerKenton M Sanders
Jun 17, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Bernard T DrummKenton M Sanders
Aug 7, 2020·American Journal of Physiology. Gastrointestinal and Liver Physiology·Anthony C JohnsonBeverley Greenwood-Van Meerveld
Jun 9, 2017·The Journal of General Physiology·Bernard T DrummSalah A Baker
Dec 8, 2019·The Journal of Physiology·Bernard T DrummKenton M Sanders
Nov 4, 2016·Nature Reviews. Gastroenterology & Hepatology·Kenton M SandersGrant W Hennig
Dec 17, 2016·American Journal of Physiology. Gastrointestinal and Liver Physiology·John MalyszGianrico Farrugia
May 28, 2019·The Journal of Physiology·Bernard T DrummKenton M Sanders
Sep 3, 2020·American Journal of Physiology. Gastrointestinal and Liver Physiology·Nicolas Rémy ChevalierSandrine Faure

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