Spontaneous calcium release induced by ethanol in the isolated rat brain microsomes

Brain Research
J Shah, H C Pant

Abstract

Ethanol-induced neurotransmitter release in unstimulated synaptosomes was found to be independent of extrasynaptosomal Ca2+ concentration, indicating a redistribution of intracellular Ca2+. The effects of alcohol on microsomal Ca2+ uptake and release were studied. In vitro addition of 100 mM ethanol had no effect on ATP-dependent Ca2+ accumulation in the microsomes. However, the same amount of ethanol released 25% of total accumulated Ca2+ from the microsomes. Ethanol induced Ca2+ release in a concentration-dependent manner over the range 30 mM-500 mM. The amount of Ca2+ release increased with higher alcohols. The effect of alcohol was temperature-dependent and inhibited at 0 degrees C. These results indicate that the known stimulatory effects of ethanol on resting release of neurotransmitters may be due to the microsomal release of Ca2+.

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Apr 15, 1990·Biochemical Pharmacology·M DavidsonB Shanley
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Aug 4, 2004·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·María Dolores MayasJosé Manuel Martínez-Martos

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