Spontaneous cervical artery dissection: a fluoroquinolone induced connective tissue disorder?

Chiropractic & Manual Therapies
James S Demetrious

Abstract

Spontaneous cervical artery dissections more often manifest in young people and have been associated with catastrophic consequences. Some indeterminate risk factors have been identified, making the diagnosis of developing dissections quite difficult. Fluoroquinolone antibiotics have been recognized for their degradative effects on connective tissue. Recent studies have implicated fluoroquinolones in the genesis of aortic artery aneurysms. It is the purpose of this paper to provide reasoning for a testable hypothesis of whether fluoroquinolones constitute a risk factor associated with cervical artery dissections. A PubMed search was conducted to investigate whether cervical artery dissection has been associated with fluoroquinolone use. An assessment of risk factors was made of hereditary connective tissue disorders, infection, and seasonal predisposition related to cervical artery dissection. These factors were considered in conjunction with reports of connective tissue toxicity associated with fluoroquinolone medications. It appears that no reported cases of cervical artery dissection have previously been correlated with fluoroquinolone use. Heritable connective tissue disorders, infection, seasonal predisposition and conditio...Continue Reading

References

Jul 15, 1999·Archives of Neurology·A J GrauW Hacke
May 27, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Yasmin Khaliq, George G Zhanel
Jun 14, 2003·Stroke; a Journal of Cerebral Circulation·Benoît GuillonChristophe Tzourio
Apr 15, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·M PaciaroniR W Baumgartner
Sep 27, 2006·Neurology·M ArnoldR W Baumgartner
Oct 3, 2012·The American Journal of Medicine·Barton L WiseYuqing Zhang
Mar 5, 2014·Antimicrobial Agents and Chemotherapy·Katie J SudaThomas H Taylor
Oct 6, 2015·JAMA Internal Medicine·Chien-Chang LeeShan-Chwen Chang
Oct 7, 2015·BMJ Case Reports·Beatrice Alexandra GolombAlan J Redd
Jul 26, 2017·The American Journal of Medicine·Sonal Singh, Amit Nautiyal
Mar 10, 2018·BMJ : British Medical Journal·Björn PasternakHenrik Svanström

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Citations

Apr 18, 2021·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Onur Serdar GenclerAydın Aslan

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Methods Mentioned

BETA
dissections
dissection

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