Spontaneous Changes in Functional Connectivity of Independent Components of fMRI Signal in Healthy Volunteers at Rest and in Subjects with Mild Depression

Bulletin of Experimental Biology and Medicine
D D BezmaternykhK A Natarova

Abstract

Depression is associated with changes in the pattern of interaction of cerebral networks, which can reflect both existing symptoms and compensatory processes. The study is based on analysis of resting state fMRI data from 15 patients with mild depression and 19 conventionally healthy individuals. From fMRI signal recorded at rest for 4 min, the independent components were reconstructed. The intergroup differences and dynamics of functional connectivity from the first to the second recording were analyzed. Initially, depressive patients demonstrated weaker connectivity between cerebellar declive network (CN) and left central executive network (CEN) and also sensorimotor network (SMN); left CEN and primary visual network (PVN). During the second recording, the patients demonstrated more intensive reciprocal connection of the dorsal domain of default mode network (DMN) and auditory network (AN). In healthy subjects, positive correlations of the dorsal DMN and left CEN, right CEN and CN, and negative correlation of dorsal DMN and visuospatial network weakened from the first to second record. In the depression group, the interaction of AN with PVN, the right CEN with the anterior salience network and with ventral DMN weakened. At th...Continue Reading

References

Oct 5, 2011·Molecular Psychiatry·H TaoJ Feng
Oct 4, 2014·Journal of Psychiatric Research·Angel BuchananJackie K Gollan
Nov 28, 2015·Human Brain Mapping·Roberto Goya-MaldonadoOliver Gruber
Aug 30, 2016·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Jiu ChenZhijun Zhang
Aug 31, 2017·Bulletin of Experimental Biology and Medicine·M E Mel'nikovK A Natarova

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Citations

Aug 21, 2018·Bulletin of Experimental Biology and Medicine·D D BezmaternykhK A Natarova

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