PMID: 2120187Oct 1, 1990Paper

Spontaneous deletion formation within the beta-galactosidase gene of Lactobacillus bulgaricus

Journal of Bacteriology
B Mollet, M Delley

Abstract

To investigate the genetic stability of the dairy organism Lactobacillus bulgaricus, we have analyzed 107 spontaneous mutations of the beta-galactosidase gene of this organism. Ten of these mutations were DNA rearrangements giving rise to different deletions, located predominantly within a small hot spot area. The DNA sequences of the different deletion junctions have been determined. The analysis showed that the deletions can be divided into two classes, depending on the presence of short direct-repeat sequences at the deletion endpoints and on the length of the deleted sequences. Possible mechanisms of these deletion formations and the involvement of inverted-repeat sequences that may enhance slipped DNA mispairing are discussed.

References

Sep 6, 1976·Biochimica Et Biophysica Acta·J M TaylorJ Summers
Dec 25, 1979·Journal of Molecular Biology·F W StudierJ J Dunn
Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Dec 25, 1978·Journal of Molecular Biology·D J Galas
Apr 1, 1989·Molecular & General Genetics : MGG·J Casadesus, J R Roth
Jun 1, 1989·Molecular & General Genetics : MGG·J C Pierce, W Masker
Apr 1, 1989·Journal of Bacteriology·B MichelS D Ehrlich
Apr 1, 1989·Genetics·K Weston-Hafer, D E Berg
May 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·B Michel, S D Ehrlich
Dec 1, 1988·Applied and Environmental Microbiology·B BoizetB M Chassy
Jun 1, 1988·Molecular & General Genetics : MGG·B P PeetersG Venema
Jul 20, 1988·Journal of Molecular Biology·B S Singer, J Westlye
Jun 1, 1985·Journal of Bacteriology·J Hahn, D Dubnau
Aug 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·P LopezS A Lacks
Jan 24, 1981·Nucleic Acids Research·J MessingP H Seeburg
Jan 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·C Egner, D E Berg
Jan 1, 1981·Annual Review of Genetics·N Kleckner
Jan 1, 1982·Molecular & General Genetics : MGG·I M JonesS D Ehrlich
Jan 1, 1983·Cold Spring Harbor Symposia on Quantitative Biology·L S Ripley, B W Glickman
Jan 11, 1984·Nucleic Acids Research·J DevereuxO Smithies
Jan 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·B W Glickman, L S Ripley
Jun 1, 1990·Applied and Environmental Microbiology·M DelleyH Hottinger

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Citations

Nov 1, 1991·Journal of Dental Research·I UshiroR R Russell
Nov 1, 1994·Molecular & General Genetics : MGG·M C Zwahlen, B Mollet
Oct 1, 1996·Antonie van Leeuwenhoek·B E DavidsonA J Hillier
Sep 30, 2004·Journal of Dairy Science·C MonnetG Corrieu
Aug 30, 1995·Molecular & General Genetics : MGG·J E GermondB Mollet
Oct 1, 1994·FEMS Microbiology Reviews·W M de Vos, E E Vaughan
Oct 1, 1996·Antonie van Leeuwenhoek·W M de Vos
Jan 25, 2002·Journal of Bacteriology·Luciane LapierreJacques-Edouard Germond
Jul 1, 1992·Journal of Bacteriology·S DavidW M de Vos
Jul 20, 2006·Microbial Cell Factories·Catherine M BurgessDouwe van Sinderen

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