Spontaneous diabetes mellitus in captive Mandrillus sphinx monkeys: a case report

Journal of Medical Primatology
N PiraratS Assarasakorn

Abstract

Case history The two obese mandrills (Mandrillus sphinx) showed clinical signs of depression, anorexia, hyperglycemia, hypertriglyceridemia, glucosuria, proteinuria and ketonuria. Septic bed sore wounds were noted on both fore and hind limbs. Results Histopathological study revealed severe islet amyloidosis in both mandrills. Immunohistochemical study using polyclonal anti-cat amylin antibody confirmed derivation of the islet amyloid from islet amyloid polypeptide (IAPP). Cardiomyopathy and myocardial fibrosis were also evident. Conclusions The present study documents diabetes mellitus in two obese mandrills. Diabetes in these animals had features very similar type 2 diabetes mellitus of humans, including the development of severe, IAPP-derived islet amyloidosis. The mandrill may, therefore, serve as an animal model of human type 2 diabetes mellitus.

References

Jun 15, 1990·Biochemical and Biophysical Research Communications·U HellmanK H Johnson
Oct 1, 1990·Diabetes Research and Clinical Practice·K InoueH Nawata
Jul 6, 1989·The New England Journal of Medicine·R E JohnsonC B Snowden
Dec 8, 1989·The American Journal of Medicine·T D Giles, G E Sander
Aug 10, 2000·The New England Journal of Medicine·J W HöppenerC J Lips
May 7, 2002·Journal of Medical Primatology·G B HubbardK M Brasky
Jul 12, 2002·Journal of Medical Primatology·G B HubbardM M Leland
Oct 22, 2003·Archives of Biochemistry and Biophysics·George JerumsMark Cooper
Jan 6, 2004·Acta Diabetologica·J Skrha

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Citations

Jun 11, 2009·American Journal of Primatology·Barbara A BeamanUlrich H Reichard
Jul 10, 2012·Journal of Diabetes Science and Technology·H James HarwoodJanice D Wagner
Oct 12, 2019·Scientific Reports·Wenji YuanMasayuki Shimoda
Aug 1, 2012·Zoo Biology·C W KuharP M Dennis

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