PMID: 7007801Jan 1, 1981Paper

Spontaneous diabetes mellitus in the New Zealand white rabbit: physiologic characteristics

Metabolism: Clinical and Experimental
H H ConawayL L Sanders

Abstract

Spontaneous diabetes mellitus has been observed in a female New Zealand white rabbit. By inbreeding of this individual and her offspring, 39 litters comprising 157 animals have been studied and a closed colony of diabetic rabbits established. Three groups of animals can be identified. Twenty-nine (19%) have overt diabetes characterized by fasting hyperglycemia and depressed intravenous glucose stimulated serum insulin levels. This abnormality is seen between 1 and 3 yr of life. Forty-three of the animals (27%) have developed abnormal glucose disposal with normal or slight elevations in fasting serum glucose levels. Glucose stimulated insulin levels are also significantly lower in the rabbits with abnormal glucose disposal. The remaining 85 animals (54%) exhibit no apparent abnormalities of glucose metabolism. All animals with overt diabetes pass through a stage in which glucose disposal as measured by k values is less than 1.0, a value not observed in normal animals. Fasting and arginine stimulated glucagon levels were no different in 4 diabetic animals and 7 normal colony rabbits. Insulin therapy corrected the hyperglycemia in the diabetic rabbits. Insulin was withheld in 5 diabetic rabbits and serum and urinary glucose and ke...Continue Reading

References

Apr 1, 1966·Endocrinology·J N FainR O Scow
Nov 1, 1972·Diabetes·D P CameronA E Renold
Sep 1, 1971·The Journal of Clinical Investigation·W A MüllerR H Unger
Apr 1, 1970·The Journal of Clinical Investigation·R H UngerA M Eisentraut

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Citations

Mar 16, 2013·Acta histochemica·Rosa María Vigueras-VillaseñorJulio César Rojas-Castañeda
Apr 9, 2016·Veterinary World·Tossou Jacques Dougnon, Messanvi Gbeassor
Feb 24, 1998·Metabolism: Clinical and Experimental·K Tokuyama, M Suzuki
May 1, 1982·Metabolism: Clinical and Experimental·H K WilsonH H Conaway
Aug 1, 1981·Biochemical Medicine·F H FaasM D Morris

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