Spontaneous discharge and response characteristics of central otolith neurons of rats during postnatal development

Neuroscience
C H Lai, Y S Chan

Abstract

To study the developmental profile of otolith-related vestibular nuclear neurons, their spontaneous activities and response dynamics were examined in decerebrate rats aged seven, 14, 21 and 84 (adult) days. Extracellular recordings were performed in the lateral and descending vestibular nucleus of animals held at the stationary position in the earth-horizontal or subjected to constant velocity off-vertical axis rotation, which selectively stimulates the otolith receptors. All neurons displayed sinusoidal position-dependent modulation in discharge rate, indicating their capability in coding spatial information during low-frequency head movement. Some neurons showed a full-cycle response to off-vertical axis rotation (non-clipped), while other neurons were silenced in discharge during parts of each rotary cycle (clipped). In seven-day-old rats, three-quarters of the responsive neurons sampled were clipped and the proportion progressively decreased to less than one-quarter in adult rats. In each age group, the clipped neurons discharged in approximately 60% of the stimulus cycle. Response gains of the neurons increased with age, reaching a plateau from 21 days of age for clipped neurons and 14 days for non-clipped neurons. The cli...Continue Reading

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Citations

May 10, 2006·Experimental Brain Research·Ying-Shing ChanDaisy Kwok-Yan Shum
Jun 16, 2005·Neuroscience Letters·Chuan LiYing-Shing Chan
Jul 18, 2001·Neuroscience Letters·M MathonnetC Ayer-Le Lièvre
Feb 3, 2004·The Journal of Comparative Neurology·Chun-Hong LaiYing-Shing Chan
May 19, 2006·The European Journal of Neuroscience·Suk-King LaiYing-Shing Chan

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