Spontaneous dwarf rat: a novel model for aging research

Geriatrics & Gerontology International
Kazunao KuramotoTadashi Shinkai

Abstract

Dwarf animal models can provide new models for aging research. For the spontaneous dwarf rat (SDR), a dwarf strain derived from the Sprague-Dawley (SD) rat, no data relevant to aging research are available. The present study aimed to examine its growth, hormonal background, lifespan and age-related diseases. Male SDR and SD rats were used for growth comparison and for immunohistochemistry and plasma hormonal analysis. SDR of each sex were maintained until natural death and then inspected pathologically. SDR showed an apparent dwarfism in their youth. Immunohistochemistry indicated that the development of growth hormone (GH)-positive cells in the pituitary was insufficient in SDR. In SDR, plasma GH levels were lower than in SD rats. Moreover, both insulin-like growth factor-1 (IGF-1) and insulin levels were decreased compared to levels in SD rats. Male and female SDR showed a mean lifespan of 29.3 +/- 3.3 and 26.8 +/- 5.3 months, respectively. The main neoplastic lesions in SDR were pituitary and mammary tumors. Major non-neoplastic lesions were incisor malocclusion, heart disease, chronic nephropathy (male) and cerebral hemorrhage (female). Most cases of chronic nephropathy were mild. Compared with longevity data and pathologic...Continue Reading

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Citations

Jun 6, 2013·Oxidative Medicine and Cellular Longevity·Ben NieJian-Ping Cai
Aug 2, 2012·Experimental Animals·Hideyuki YamatoyaNoriaki Miyoshi
Jun 23, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Gabor A FulopAnna Csiszar
Dec 1, 2018·Endocrine Reviews·Cesar Luiz Boguszewski, Margaret Cristina da Silva Boguszewski

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