PMID: 9433341Jan 20, 1998Paper

Spontaneous dyskinesia in subjects with schizophrenia spectrum personality

The American Journal of Psychiatry
S L CassadyG K Thaker

Abstract

The study of spontaneous dyskinesia in schizophrenia is confounded by the widespread use of neuroleptics. The authors hypothesized that spontaneous dyskinesia would be present in subjects with schizophrenia spectrum personality (schizoid, paranoid, or schizotypal). They also tested the hypothesis that dyskinetic-like movements would increase after repeated dextroamphetamine challenge to the dopaminergic system. Dyskinetic-like movements were assessed in 34 spectrum subjects and 22 normal subjects; nine subjects from each group were administered both placebo and repeated dextroamphetamine challenges. Spectrum subjects had more dyskinetic-like movements than normal subjects. Spontaneous dyskinesia was present in 12% of the spectrum subjects but was not seen in the normal subjects. Subjects with schizotypal personality had more dyskinetic-like movements than subjects with schizoid personality or normal subjects. Dyskinesia was present in 24% of the schizotypal subjects but not in the other groups. Dyskinetic movement scores correlated with positive symptom scores. With repeated amphetamine challenge, normal subjects showed a pattern of behavioral sensitization (an increase in dyskinetic-like movements), but spectrum subjects showe...Continue Reading

Citations

Aug 27, 1999·Schizophrenia Research·C S Neumann, E F Walker
Feb 1, 2003·Pharmacology & Therapeutics·Christine Konradi, Stephan Heckers
Jul 7, 2007·The International Journal of Neuroscience·Uner Tan
Mar 13, 2002·The Laryngoscope·John M SchweinfurthMark S Courey
Sep 24, 2011·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Aviva Berkovich-OhanaAbraham Goldstein
Nov 26, 2005·Schizophrenia Research·Sarah I Tarbox, Michael F Pogue-Geile
Oct 21, 2004·The Cochrane Database of Systematic Reviews·S NolteG Lachford
May 1, 2004·Journal of Clinical Psychopharmacology·Charles E DeanSean M Nugent
May 23, 2002·Clinical Neuropharmacology·Robert L Rodnitzky

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here