Spontaneous echo contrast caused by platelet and leukocyte aggregates?

Stroke; a Journal of Cerebral Circulation
R J ZotzH Darius

Abstract

Spontaneous echocardiographic contrast (SEC) is correlated to clinical thromboembolic events. We sought to determine the origin of SEC by utilizing direct analysis of left atrial blood. We examined the blood of 13 patients with and 19 without SEC. Blood samples were taken from the femoral vein and artery and from the right and left atria after transseptal puncture. Samples were incubated with fluorescence-labeled antibodies directed against the platelet (CD41a-PE, CD42b-PE, and CD62p-FITC) and leukocyte membrane epitopes (CD45-APC and CD14-FITC). The expressed epitopes were analyzed by dual laser flow cytometry immediately after blood withdrawal. In the peripheral blood of both groups, more activation and aggregation were found in the venous blood than in the arterial blood (CD41a, P=0.007; CD14neutro, P=0.017; and leukocyte-platelet aggregates [LTAg], P=0.002). In patients without SEC, the degree of activation and aggregation of the cardiac samples closely resembled the results of the peripheral samples. The degree of activation and aggregation was significantly higher in the right atrium than in the left atrium (LTAg, P<0.01; leukocyte activation, P<0.01; CD41a, P<0.01; CD62p, P<0.02). In contrast, in patients with SEC the pa...Continue Reading

References

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Citations

Apr 2, 2003·The American Journal of Cardiology·Christos PitsavosPavlos Toutouzas
Feb 25, 2003·Journal of the American College of Cardiology·Raymonda RastegarMartin E Goldman
Jul 23, 2008·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Svetlana G UzlovaGeorgy Th Guria
Jun 14, 2013·BMC Cardiovascular Disorders·Rui ProvidênciaAntónio M Leitão-Marques
Jan 29, 2016·The International Journal of Cardiovascular Imaging·Michael MarklJeffrey J Goldberger
Jun 25, 2013·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Rui ProvidênciaSérgio Barra
Apr 29, 2014·Ultrasound in Medicine & Biology·Hung-Yi HsuHan-Hwa Hu
Aug 10, 2013·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Rui ProvidênciaSérgio Barra
Dec 28, 2012·Neurologia Medico-chirurgica·Masahito KawaboriKiyohiro Houkin
Jan 27, 2007·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Hisao OnozukaAkira Kitabatake

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