PMID: 11927684Apr 3, 2002Paper

Spontaneous electrical activity and associated changes in calcium concentration in guinea-pig gastric smooth muscle

The Journal of Physiology
Hiroyasu FukutaHikaru Suzuki

Abstract

Spontaneous electrical activity and internal Ca(2+) concentration ([Ca(2+)](i)) were measured simultaneously using conventional microelectrodes and fura-2 fluorescence, respectively, in isolated circular smooth muscle bundles of the guinea-pig gastric antrum. The smooth muscle bundles generated periodic slow potentials with accompanying spike potentials and associated transient increases in [Ca(2+)](i) (Ca(2+)-transients). Nifedipine abolished the spike potentials but not the slow potentials, and reduced the amplitude of associated Ca(2+)-transients. Caffeine, in the absence or presence of ryanodine, reduced resting [Ca(2+)](i) levels and abolished the slow potentials and associated Ca(2+)-transients. Depolarization elevated and hyperpolarization reduced resting [Ca(2+)](i) levels with associated changes in the frequency of slow potentials. The amplitude of Ca(2+)-transients changed in a bell-shaped manner with the membrane potential change. Slow potentials and associated Ca(2+)-transients were abolished if [Ca(2+)](i) levels were reduced by BAPTA-AM or if the internal Ca(2+) pump was inhibited by cyclopiazonic acid. 2-Aminoethoxy-diphenylborate (2-APB), a known inhibitor of inositol trisphosphate (IP(3))-mediated Ca(2+) releas...Continue Reading

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Citations

Aug 19, 2004·Pflügers Archiv : European journal of physiology·Eri Nakamura, Hikaru Suzuki
Jan 20, 2007·Pflügers Archiv : European journal of physiology·Yoshihiko Kito, Hikaru Suzuki
Nov 30, 2010·Bulletin of Experimental Biology and Medicine·G I Lobov, M N Pan'kova
Apr 13, 2006·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Jae Boum YoumYung E Earm
Jun 1, 2012·Zhurnal evoliutsionnoĭ biokhimii i fiziologii·A V Bursian
Mar 3, 2004·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Eri NakamuraHikaru Suzuki
Mar 25, 2006·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Aya HottaHikaru Suzuki
Apr 17, 2007·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Young Chul KimHikaru Suzuki
May 17, 2006·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Eri NakamuraHikaru Suzuki
Feb 24, 2009·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Kazumasa DomaeHikaru Suzuki
Sep 29, 2009·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Eri NakamuraHikaru Suzuki
Oct 8, 2011·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Yuhsuke ShigemasaHikaru Suzuki
Dec 26, 2003·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Miyako Takaki
Dec 26, 2003·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Yoshihiko Kito, Hikaru Suzuki
Oct 24, 2003·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Satoshi YonedaHikaru Suzuki
Aug 30, 2002·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Hikaru SuzukiYoshimichi Yamamoto
Apr 26, 2003·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Hikaru SuzukiYoshimichi Yamamoto
Apr 26, 2003·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Yoshihiko KitoFrank R Edwards
Sep 9, 2004·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Eri NakamuraHikaru Suzuki
Jan 19, 2005·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Eri NakamuraHikaru Suzuki
Nov 1, 2005·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Aya HottaHikaru Suzuki
Jan 2, 2003·The Journal of Physiology·Yoshihiko Kito, Hikaru Suzuki
Aug 16, 2002·The Journal of Physiology·Yoshihiko KitoHikaru Suzuki
Jun 10, 2003·The Journal of Physiology·G D S Hirst, S M Ward
Jun 15, 2004·The Journal of Physiology·G D S HirstF R Edwards
Jan 31, 2004·British Journal of Pharmacology·Hikaru Hashitani, Hikaru Suzuki
Nov 6, 2007·Journal of Cellular and Molecular Medicine·Shinsuke NakayamaHong-Nian Liu
Feb 8, 2005·Biochemical and Biophysical Research Communications·Hong-Nian LiuShinsuke Nakayama
Apr 28, 2004·Cell Calcium·Damon PoburkoCornelis van Breemen
Jul 19, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Seong Jin ChoYeon-Hee Ryu
Jul 21, 2006·Biology of Reproduction·Marco MeweRalf Middendorff
Sep 2, 2006·The Journal of Physiology·H SuzukiE Nakamura
Feb 15, 2018·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Abdullah Al Kafee, Aydin Akan
Aug 2, 2008·Zhurnal evoliutsionnoĭ biokhimii i fiziologii·A V Bursian

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