Spontaneous electrical activity in the prostate gland

Autonomic Neuroscience : Basic & Clinical
Betty ExintarisRichard J Lang

Abstract

The cellular mechanisms that underlie the initiation, maintenance and propagation of electrical activity in the prostate gland remain little understood. Intracellular microelectrode recordings have identified at least two distinct electrical waveforms: pacemaker potentials and slow wave activity. By analogy with the intestine, we have proposed that pacemaker activity arises from a morphologically distinct group of c-Kit positive interstitial cells that lie mainly between the glandular epithelium and smooth muscle layers. We speculate that pacemaker activity arising from the prostatic interstitial cells (PICs) is likely to propagate and initiate slow wave activity in the smooth muscle cells resulting in contraction of the stromal smooth muscle wall. While spontaneous electrical activity in the prostate gland is myogenic in origin, it is clear that nerve-mediated agents are able to modulate this activity. Excitatory agents such as histamine, phenylephrine and a raised potassium saline all increase slow wave discharge. In contrast, nitric oxide donors reduce or abolish the spontaneous electrical events. However, the cellular mechanisms underlying the action of various endogenously released agents remain to be elucidated.

References

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Aug 18, 2004·The Journal of Urology·Richard J LangBetty Exintaris

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Citations

Jun 1, 2012·Zhurnal evoliutsionnoĭ biokhimii i fiziologii·A V Bursian
Feb 24, 2009·European Journal of Pharmacology·Dan-Thanh T NguyenBetty Exintaris
Feb 5, 2008·Brain Research Reviews·Miguel Carro-Juárez, Gabriela Rodríguez-Manzo
Aug 26, 2010·British Journal of Pharmacology·Anupa DeyBetty Exintaris
Mar 18, 2011·British Journal of Pharmacology·S VenturaB Exintaris
Feb 27, 2010·Journal of Cellular and Molecular Medicine·Hikaru Hashitani, Richard J Lang
Jun 28, 2017·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Richard J Lang, Hikaru Hashitani
May 6, 2019·PloS One·Youssef Belhamadia, Justin Grenier
Jan 31, 2008·The Journal of Biological Chemistry·Florian GackièrePascal Mariot

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