Abstract
The cynomolgus macaque is the most commonly used nonhuman primate in nonclinical toxicity testing, but the impact of the geographic source of cynomolgus macaque on differences in spontaneous pathology and response to xenobiotics has only recently been explored. Previous work from the authors' facility has described spontaneous cardiac findings in predominantly Indonesian-source animals; however, the authors have recently observed a novel spectrum of cardiac findings in Mauritian-source animals. This review evaluated the spontaneous macroscopic and microscopic cardiac findings in vehicle control Mauritian-source macaques used for routine toxicity testing. When compared to the prior review in predominantly Indonesian macaques, a higher incidence of myocardial degeneration was observed with additional novel findings including macroscopic and microscopic subendocardial hemorrhage with hemosiderin, myocardial fibrosis, and arterial medial degeneration/hemorrhage. Other findings including inflammatory cell infiltrates, anisokaryosis, and squamous plaques were observed with a comparable incidence as previously reported in Indonesian macaques. Myocardial degeneration, subendocardial hemorrhage, and myocardial fibrosis can mimic test-ar...Continue Reading
References
Jul 1, 1973·Psychosomatic Medicine·K C CorleyJ Greenhoot
Jan 31, 1969·Annals of the New York Academy of Sciences·K I MelvilleJ Knaack
Dec 18, 2001·Chest·C E EpsteinL L Fan
Nov 15, 2002·Transplantation Proceedings·K MenningerM Bigaud
Oct 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kendall C KrebsDavid H O'Connor
Mar 2, 2006·Toxicologic Pathology·Charlotte M Keenan, Justin D Vidal
Sep 21, 2006·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Elodie Drevon-GaillotRoger Burnett
Jul 4, 2007·Circulation·Martin A Samuels
Feb 12, 2008·Molecular Ecology·M BonhommeB Crouau-Roy
Mar 4, 2009·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Francisco J B Sampaio
Apr 3, 2009·Journal of Virology·Benjamin J BurwitzDavid H O'Connor
Citations
Feb 14, 2012·Toxicologic Pathology·Sheila C MacriAndrew D Miller
Apr 7, 2012·Journal of Toxicologic Pathology·Junko SatoIsao Narama
Mar 10, 2016·Journal of Pharmacological and Toxicological Methods·Andrea Greiter-WilkeAnnette Koerner
Jul 26, 2011·Journal of Medical Primatology·J Satkoski TraskD G Smith
May 23, 2012·Journal of Pharmacological and Toxicological Methods·Ray W ChuiHugo M Vargas
Dec 6, 2012·Blood·Thomas A WaldmannJohn C Morris
Mar 29, 2011·Veterinary Pathology·M M SwindleK S Frazier
Feb 27, 2015·Toxicologic Pathology·Jeffery A EngelhardtUNKNOWN Society of Toxicologic Pathology Vascular Injury Working Group
Feb 3, 2012·Toxicologic Pathology·Michael E DunnIgor Mikaelian
Nov 9, 2012·Veterinary Pathology·V G SassevilleL J Lowenstine
Oct 19, 2016·Toxicologic Pathology·Karyn Colman
Oct 19, 2016·Toxicologic Pathology·Peter HoffmannSteve Busch
May 3, 2013·Expert Review of Clinical Immunology·Steven N Steinway, Thomas P Loughran
Mar 11, 2020·Cardio-Oncology·Eugene Herman, Sandy Eldridge
Aug 29, 2020·Toxicologic Pathology·Steven T LaingHelen S Booler
Feb 27, 2018·Journal of Toxicologic Pathology·Shizuka KonishiMakoto Ueda
May 16, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Changhua JiBernard S Buetow