Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging

Nature Reviews. Neuroscience
Michael D Fox, Marcus E Raichle

Abstract

The majority of functional neuroscience studies have focused on the brain's response to a task or stimulus. However, the brain is very active even in the absence of explicit input or output. In this Article we review recent studies examining spontaneous fluctuations in the blood oxygen level dependent (BOLD) signal of functional magnetic resonance imaging as a potentially important and revealing manifestation of spontaneous neuronal activity. Although several challenges remain, these studies have provided insight into the intrinsic functional architecture of the brain, variability in behaviour and potential physiological correlates of neurological and psychiatric disease.

References

Jan 1, 1991·Journal of Veterinary Internal Medicine·C E Reusch, E C Feldman
Apr 1, 1988·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·B A VernM Radulovacki
Jan 1, 1984·Advances in Experimental Medicine and Biology·J ManilR Paternoster
Mar 24, 1995·Science·D L GildenM W Mallon
Jan 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K J FristonR S Frackowiak
Oct 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·B BiswalJ S Hyde
Jan 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·C J Shatz
Mar 1, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·B BiswalJ S Hyde
Jan 22, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·S J LiE A Stein
Jul 14, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·G H GloverD Ress
Nov 22, 2000·Brain Research. Brain Research Reviews·A Ames
Feb 24, 2001·Proceedings of the National Academy of Sciences of the United States of America·M E RaichleG L Shulman
Feb 24, 2001·Psychological Review·D L Gilden
Apr 3, 2001·Nature Reviews. Neuroscience·F VarelaJ Martinerie
Jun 30, 2001·Journal of Neurophysiology·M Steriade
Aug 3, 2001·Nature Reviews. Neuroscience·E Salinas, T J Sejnowski
Sep 26, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·E A Maguire
Oct 5, 2001·Nature Reviews. Neuroscience·A K EngelW Singer
Oct 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·C E Stark, L R Squire
Oct 13, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·D Attwell, S B Laughlin
Feb 9, 2002·Human Brain Mapping·Michelle HampsonJohn C Gore
Apr 24, 2002·NeuroImage·Martin A KochMargret Hund-Georgiadis
May 8, 2002·Nature Reviews. Neuroscience·Maurizio Corbetta, Gordon L Shulman
Aug 8, 2002·Magnetic Resonance Imaging·Dietmar CordesKen Maravilla
Aug 31, 2002·NeuroImage·S J Peltier, D C Noll
Dec 31, 2002·Proceedings of the National Academy of Sciences of the United States of America·Michael D GreiciusVinod Menon
Mar 11, 2003·Nature Neuroscience·David Ress, David J Heeger
Mar 21, 2003·Current Biology : CB·Peter Lennie
Apr 22, 2003·Annual Review of Neuroscience·Alexandre PougetRichard S Zemel

❮ Previous
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Citations

Jul 25, 2009·Experimental Brain Research·David Balin ChorlianBernice Porjesz
Jun 7, 2011·Experimental Brain Research·Paige E ScalfDiane M Beck
Feb 27, 2008·European Journal of Nuclear Medicine and Molecular Imaging·Marc WermkeAlexander Drzezga
Jul 16, 2009·Journal of Neurology·Lars FringsKathrin Wagner
Oct 12, 2012·Journal of Neurology·Massimo FilippiMaria Assunta Rocca
Sep 25, 2009·European Journal of Applied Physiology·Pengxu WeiShujia Liu
Jun 1, 2010·Brain Structure & Function·Philipp Sterzer, Andreas Kleinschmidt
Jun 1, 2010·Brain Structure & Function·Vinod Menon, Lucina Q Uddin
Mar 1, 2012·Brain Structure & Function·Michael P HarmsDeanna M Barch
May 16, 2012·Brain Structure & Function·Anne-Lise PitelEdith V Sullivan
Nov 13, 2012·Brain Structure & Function·C RottschyS B Eickhoff
Oct 18, 2011·Journal of Neural Transmission·L KrajcovicovaIrena Rektorova
Jun 15, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Cristina Rosazza, Ludovico Minati
May 18, 2010·Magma·Philipp G SämannMichael Czisch
Dec 31, 2009·Cognitive Processing·Antonino Raffone, Narayanan Srinivasan
Apr 24, 2013·Journal of Inherited Metabolic Disease·Barbara BorroniA Padovani
Nov 20, 2012·Brain Topography·R L O'GormanL Michels
Feb 13, 2013·Brain Topography·Ivan RektorIrena Rektorová
Aug 12, 2009·Journal of Biological Physics·Massimiliano IgnaccoloBruce J West
Sep 8, 2010·Bulletin of Mathematical Biology·Moira L Steyn-RossM T Wilson
Jun 7, 2012·Brain Imaging and Behavior·Semyon SlobounovKai Zhang
Jun 8, 2012·Brain Imaging and Behavior·Andrew R MayerKasra Mojtahed
Jul 4, 2012·Science and Engineering Ethics·Ralph J Greenspan
Oct 16, 2012·Neuroinformatics·Bao GeTianming Liu
Jul 27, 2012·Neuroscience Bulletin·Ming Song, Tianzi Jiang
Jun 11, 2009·The Cerebellum·Christophe Habas

❮ Previous
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