Spontaneous formation of bilayers and vesicles in mixtures of single-chain alkyl carboxylates: effect of pH and aging and cytotoxicity studies

Langmuir : the ACS Journal of Surfaces and Colloids
N VlachyW Kunz

Abstract

We report the observation of bilayer fragments, some of which close to form vesicles, over a large range of pH at room temperature from mixtures of single-chain biocompatible commercially available nontoxic alkyl carboxylic surfactants after neutralization with HCl. The pH at which the morphological transitions occur is varied only by changing the ratio between two surfactants: the alkyloligoethyleneoxide carboxylate and sodium laurate. The effect of aging of the mixed surfactant systems in the pH region desired for dermatologic application (4.5 < pH < 7) is also studied. Finally, we show results of cytotoxicity studies on the surfactant mixtures.

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Citations

May 7, 2011·The Journal of Physical Chemistry. B·Yixiu HanHongyan Wang
Dec 26, 2012·Journal of Colloid and Interface Science·Yongmin ZhangYujun Feng
Jan 29, 2011·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Anshupriya ShomePrasanta K Das
Dec 6, 2014·Journal of Colloid and Interface Science·Yongmin Zhang, Yujun Feng
Aug 2, 2016·Advances in Colloid and Interface Science·Stefan WolfrumWerner Kunz
Oct 18, 2019·Soft Matter·Dominic W HaywardMichael Gradzielski
May 10, 2018·Scientific Reports·Dominic W HaywardMichael Gradzielski

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