Spontaneous formation of temperature-responsive assemblies by molecular recognition of a β-cyclodextrin containing block copolymer and poly(N-isopropylacrylamide).

Soft Matter
Jianxiang ZhangPeter X Ma

Abstract

We report the construction of novel temperature-responsive assemblies based on a double hydrophilic block copolymer (consisting of a PEG block and a β-cyclodextrin-containing block, PEG-b-PCD) and poly(N-isopropylacrylamide) (PNIPAm). Thus formed nano-assemblies exhibit a spherical morphology and have a temperature-responsive loose core. The driving force for the formation of these assemblies was found to be the inclusion complexation interaction between the hydrophobic cavity of β-cyclodextrin and the isopropyl group of PNIPAm. The particle size of these assemblies changed reversibly in response to the external temperature change. The particle size also changed with the PNIPAm/PEG-b-PCD weight ratio. A model hydrophobic drug (indomethacin) was loaded into these assemblies with a high efficiency. An in vitro release study showed that the payload could be released in a sustained manner after an initial burst release. The release rate could be switched between high and low in an ON/OFF fashion by temperature. These results demonstrate that the nano-assemblies have high potential for applications in controlled drug delivery and biomedicine when temperature responsiveness is desired.

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Citations

May 14, 2011·Expert Opinion on Drug Delivery·Zhenqing Li, Jianjun Guan
Jul 17, 2012·Colloids and Surfaces. B, Biointerfaces·Yan XueHuining Xiao
Dec 4, 2014·The Journal of Physical Chemistry. B·Guihua LiJingcheng Hao
Jul 16, 2016·Colloids and Surfaces. B, Biointerfaces·Jing LvZongshi Li
Mar 4, 2017·Soft Matter·Huifang XuWanguo Hou

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