PMID: 44371Jan 1, 1979

Spontaneous generation of adriamycin semiquinone radicals at physiologic pH

Physiological Chemistry and Physics
D D PietronigroH B Demopoulos

Abstract

Adriamycin semiquinone radicals are spontaneously generated by adriamycin solutions at physiologic pH. Rate of radical formation and equilibrium-state radical yield increase with increasing pH from 7.4 to 8.85. The radicals are oxygen sensitive, but the mechanism of radical formation is oxygen independent and associated with proton removal from the dihydroquinone of adriamycin. The less cardiotoxic and non-mutagenic (Ames test) anthracycline 5-iminodaunorubicin does not form semiquinone radicals spontaneously at physiologic pH.

Related Concepts

5-iminodaunorubicin
Radicals (chemistry)
Ribodoxo
Semiquinone radicals
Adriamycin semiquinone radicals
Alkalemia
Solutions
Anthracyclines
Dihydroquinone
Anthracycline Antibiotics

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