Spontaneous hypoglycemia associated with congestive heart failure attributable to hyperinsulinism.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
H KhouryK Ehsanipoor

Abstract

To report a case of spontaneous hypoglycemia associated with congestive heart failure in an adult. We describe a 72-year-old man in whom profound hypoglycemia (serum glucose level, 21 mg/dL) developed during an exacerbation of heart failure. Clinical and laboratory data are reviewed. An inverse relationship was found between both serum insulin and C peptide levels and serum glucose level. Serum glipizide and glyburide levels were undetectable, and no insulinoma was found on radiologic imaging. Hypoglycemia resolved after alleviation of the congestive heart failure. In this case, the hypoglycemia was attributed to hyperinsulinemia. Possible mechanisms include impaired insulin degradation and shunting of portal blood into the systemic circulation.

References

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Citations

Mar 13, 2018·BMJ Open Diabetes Research & Care·Nestoras Nicolas MathioudakisSuchi Saria

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