PMID: 7336162Aug 1, 1981Paper

Spontaneous immunoglobulin changes in human plasma-cell dyscrasia

Scandinavian Journal of Haematology
A CarterI Tatarsky

Abstract

A series of spontaneous changes affecting the nature of the immunoglobulin secretion of plasma cels is described in a patient initially diagnosed as IgG lambda benign monoclonal gammopathy. After several years a slight increase in the amount of serum monoclonal immunoglobulin occurred; shortly thereafter an aggressive form of multiple myeloma was diagnosed. Unexpectedly a rapid spontaneous decrease of the monoclonal immunoglobulin, accompanied by the appearance in the serum of increasing quantities of a complex containing intact lambda light chains, then occurred. Concomitantly a fragment of the corresponding free light chain was was detected in the urine. A parallel is drawn between the facts observed in this patient and in an animal model recently proposed to explain the different types of structural immunoglobulin abnormalities in multiple myeloma.

References

Mar 1, 1979·Clinical Immunology and Immunopathology·P C NowellD Guerry
Aug 1, 1978·Cancer·D A GaltonE Wiltshaw
Oct 1, 1976·Science·P C Nowell
Apr 10, 1971·British Medical Journal·J R Hobbs
Nov 23, 1974·Lancet·S E Salmon, M Seligmann
Jul 1, 1972·Physiological Reviews·M Potter
Dec 1, 1980·British Journal of Haematology·A Carter, I Tatarsky

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Citations

Jul 1, 1984·British Journal of Haematology·B G Durie

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