Spontaneous improvement in a case of C1q nephropathy

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
M NishidaT Sawada

Abstract

A 17-year-old girl showed mild proteinuria accompanied by hematuria and mild hypocomplementemia. A light microscopic study of the first renal biopsy specimen showed diffuse mild to moderate mesangial proliferation and thickening of the glomerular basement membrane (GBM). An immunofluorescence study showed dominant positive staining (3+) of IgG and C1q in the glomerular mesangium and capillary loop. Staining for C3 and fibrinogen was weak or 1+. Staining for IgA and IgM was negative. Electron-dense deposits were present in the mesangial area and also in the subepithelial, subendothelial, and intramembranous space. Urinary findings improved after dipyridamole treatment. The second renal biopsy, which was performed 5 years later, showed histological improvements, and various pictures of washing-out of deposits were also noted in an electron microscopic study. However, dominant positive staining for IgG and C1q was persistent in an immunofluorescence study. The glomerulopathy of this case belongs in the criteria of neither membranoproliferative glomerulonephritis nor lupus nephritis but could be designated as C1q nephropathy. This is the first report of a histological improvement in C1q nephropathy.

Citations

Sep 1, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Masashi NishidaKenji Hamaoka
Mar 8, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Isabel RobertiDae Un Kim
Aug 9, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Isabel RobertiDae Un Kim
Feb 25, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Scott E WenderferMichael C Braun
Jul 24, 2012·Clinical and Experimental Nephrology·Takashi TakeiKosaku Nitta
Jul 25, 2008·Journal of the American Society of Nephrology : JASN·Alenka VizjakJ Charles Jennette
Nov 28, 2013·Nephro-urology Monthly·Pavan Malleshappa, Mahesha Vankalakunti
Dec 1, 2011·NDT Plus·Consolación Rosado RubioJosé Luis Lerma Márquez

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