Spontaneous intracerebral hemorrhage in CADASIL

The Journal of Headache and Pain
Lifei LianSuiqiang Zhu

Abstract

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a rare hereditary small vascular disease and its mainly clinical manifestations are ischemic events. Spontaneous intracerebral hemorrhage (ICH) involvement in patients with CADASIL is extremely uncommon. A 46-year-old normotensive Chinese man developed a large hematoma in the left basal ganglia after he was diagnosed with CADASIL 2 months ago, the patient did not take any antithrombotics. Susceptibility weighted imaging at pre-ICH showed multiple cerebral microbleeds (CMBs) in the bilateral basal ganglia. He experienced migraine at about 10 months post-ICH. To our knowledge, this is the first report of ICH in CADASIL patients with Arg90Cys mutation in exon 3. ICH should be considered when evaluating new attacks in CADASIL patients. Thus, MRI screening for CMBs might be helpful in predicting the risk of ICH and guiding antithrombotic therapy. In addition, strict control of hypertension and cautious use of antithrombotics may be important in this context.

References

Nov 18, 1998·Annals of Neurology·M DichgansT Gasser
Jul 19, 2001·Journal of Neurology, Neurosurgery, and Psychiatry·A ArboixC Targa
Apr 10, 2002·Acta Neurologica Scandinavica·A ArboixC Targa
Feb 18, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·A V MacleanE G Stopa
Dec 1, 2006·Neurology·Jay Chol ChoiJi-Kang Park
Jan 22, 2008·Clinical Neurology and Neurosurgery·Jung-Hwan OhJay Chol Choi
May 6, 2008·Lancet Neurology·Yining HuangUNKNOWN Cilostazol versus Aspirin for Secondary Ischaemic Stroke Prevention cooperation investigators
May 1, 2010·Stroke; a Journal of Cerebral Circulation·Caroline E LovelockPeter M Rothwell
May 21, 2011·Stroke; a Journal of Cerebral Circulation·Hirokazu BokuraShuhei Yamaguchi
Aug 20, 2011·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Jay Chol ChoiJi-Hoon Kang
Nov 1, 2011·Journal of Neurology·Miguel Viana-Baptista
Nov 16, 2011·Internal Medicine·Yasuteru SanoTakashi Kanda
Dec 31, 2011·Journal of the Neurological Sciences·Luca PradottoAlessandro Mauro
May 4, 2013·Journal of the Neurological Sciences·Valentina RinnociLeonardo Pantoni

❮ Previous
Next ❯

Citations

Apr 7, 2017·Annals of Clinical and Translational Neurology·Chen ZhangZaiqiang Zhang
Sep 10, 2015·Arquivos de neuro-psiquiatria·Maximiliano A HawkesSebastián F Ameriso
Mar 4, 2017·Clinical Neurology and Neurosurgery·Christian Baastrup SøndergaardHanne Christensen
Feb 26, 2015·Stroke; a Journal of Cerebral Circulation·Inês Menezes CordeiroCarlos Basílio
Oct 18, 2014·Brain Pathology·Saara TikkaHannu Kalimo
Jul 26, 2017·Current Treatment Options in Neurology·Anna BersanoEugenio Agostino Parati
Jan 23, 2021·Revue neurologique·P PalazzoJ-P Neau

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.