Spontaneous involution of a Rathke's cleft cyst in a patient with normal cortisol secretion.

Surgical Neurology International
Stephan A Munich, Jody Leonardo

Abstract

Rathke's cleft cyst (RCC) is a lesion derived from maldeveloped remnants of a dorsal invagination of the stomodeal ectoderm (Rathke's pouch). Although commonly found on autopsy, these lesions rarely become symptomatic during an individual's lifetime. When symptoms occur, they most often include headaches, visual disturbances, and/or varying degrees of hypopituitarism. The natural history remains unclear. The current standard of care includes surgical drainage and biopsy of the cyst wall or surgical resection of symptomatic lesions; however, debate exists regarding the management of asymptomatic lesions. Rare reports of spontaneously resolving RCC can be found in the literature. We describe the management of a case of RCC in an 8½-year-old girl who presented with a history of growth deceleration since 4 years of age and near-growth arrest since 7 years of age. Her parents also described a tendency towards polydipsia since she was 2 years of age. Endocrine evaluation revealed growth hormone deficiency, central hypothyroidism, and diabetes insipidus, but normal cortisol secretion. The patient experienced no symptoms characteristic of intracranial or sellar mass. Neurologic examination was normal; formal ophthalmologic examination ...Continue Reading

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Citations

May 8, 2019·Journal of Korean Neurosurgical Society·Chaejin Lee, Seong-Hyun Park
Dec 23, 2016·The Journal of Craniofacial Surgery·Lei ChengEnyuan Cai

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Methods Mentioned

BETA
surgical resection
biopsy of
biopsy
hormone replacement therapy
growth

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