Spontaneous ketonuria and risk of incident diabetes: a 12 year prospective study

Diabetologia
Gyuri KimNam H Cho

Abstract

Ketones may be regarded as a thrifty fuel for peripheral tissues, but their clinical prognostic significance remains unclear. We investigated the association between spontaneous fasting ketonuria and incident diabetes in conjunction with changes in metabolic variables in a large population-based observational study. We analysed 8703 individuals free of diabetes at baseline enrolled in the Korean Genome and Epidemiology Study, a community-based 12 year prospective study. Individuals with (n = 195) or without fasting ketonuria were matched 1:4 by propensity score. Incident diabetes was defined as fasting plasma glucose ≥7.0 mmol/l, post-load 2 h glucose ≥11.1 mmol/l on biennial OGTTs, or current use of glucose-lowering medication. Using Cox regression models, HRs for developing diabetes associated with the presence of ketonuria at baseline were analysed. Over 12 years, of the 925 participants in the propensity score-matched cohort, 190 (20.5%) developed diabetes. The incidence rate of diabetes was significantly lower in participants with spontaneous ketonuria compared with those without ketonuria (HR 0.63; 95% CI 0.41, 0.97). Results were virtually identical when participants with fasting ketonuria were compared against all parti...Continue Reading

References

Jul 25, 1970·Nature·D J JenkinsD V Goff
Nov 1, 1970·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·E O BalasseJ P Lambilliotte
Jan 1, 1980·Annual Review of Biochemistry·J D McGarry, D W Foster
Jan 1, 1980·Physiological Reviews·A M Robinson, D H Williamson
Jun 26, 2002·The American Journal of Clinical Nutrition·Kathy Musa-VelosoStephen C Cunnane
Jul 23, 2005·Annals of the New York Academy of Sciences·Benjamin G K BeisswengerPaul J Beisswenger
Dec 6, 2005·Diabetes Research and Clinical Practice·Andrea TuraGiovanni Pacini
Jan 16, 2007·Digestive Diseases and Sciences·David TendlerEric C Westman
Mar 21, 2008·The EMBO Journal·Sarah K KnutsonScott W Hiebert
Dec 18, 2010·Journal of Korean Medical Science·Nam-Seok JooSang-Man Kim
Apr 20, 2011·The Journal of Biological Chemistry·Anna Vilà-BrauPedro F Marrero
Apr 27, 2011·Proceedings of the National Academy of Sciences of the United States of America·Ikuo KimuraGozoh Tsujimoto
Jun 3, 2011·The Journal of Clinical Investigation·Herbert Tilg, Arthur Kaser
Apr 12, 2012·Journal of Lipid Research·Santhosh SatapatiShawn C Burgess
Jan 22, 2013·Diabetic Medicine : a Journal of the British Diabetic Association·A A KlockerM E Craig
Feb 12, 2013·American Journal of Physiology. Heart and Circulatory Physiology·David G CotterPeter A Crawford
Aug 6, 2013·Annals of the New York Academy of Sciences·Richard L Veech
Oct 22, 2013·Trends in Endocrinology and Metabolism : TEM·John C Newman, Eric Verdin
May 23, 2014·Nature Communications·Mahbubur RahmanMarkus Schwaninger
Jul 18, 2014·Endocrinology and Metabolism·Kwi-Hyun BaeKeun-Gyu Park
Sep 13, 2014·Diabetes & Metabolism Journal·Kook Hwan Kim, Myung-Shik Lee
Oct 28, 2014·The Journal of Clinical Investigation·David G CotterPeter A Crawford
Apr 11, 2015·Journal of the Academy of Nutrition and Dietetics·Ruth E PattersonLinda C Gallo
Jul 3, 2015·The American Journal of Clinical Nutrition·Benjamin D HorneJeffrey L Anderson
Nov 17, 2015·Nature Reviews. Drug Discovery·Chiara DegirolamoAntonio Moschetta
Jun 12, 2016·Diabetes Care·Ele FerranniniEric Mayoux
Jun 29, 2016·Diabetes & Metabolism Journal·Chang Yeop Han
Jul 1, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Angelia Maleah HollandMichael D Roberts

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Citations

Aug 2, 2019·Cell Cycle·Mikhail V Blagosklonny
Aug 11, 2020·Journal of Korean Medical Science·Bo Reum KimNam Seok Joo

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