PMID: 9180928May 1, 1997Paper

Spontaneous liver tumors and benzo[a]pyrene-induced lymphomas in XPA-deficient mice

Molecular Carcinogenesis
A de VriesH van Steeg

Abstract

Defects in the xeroderma pigmentosum complementation group A-correcting (XPA) gene, which encodes a component of the nucleotide excision repair (NER) pathway, are associated with the cancer-prone human disease xeroderma pigmentosum. We previously generated mice lacking the XPA gene, which develop normally but are highly sensitive to ultraviolet-B and 7,12-dimethylbenz[a] anthracene-induced skin tumors. Here we report that XPA-deficient mice spontaneously developed hepatocellular adenomas at a low frequency as they aged. Furthermore, oral treatment of XPA-deficient mice with the carcinogen benzo[a]pyrene (B[a]P) resulted in the induction of mainly lymphomas. These tumors appeared earlier and with a higher incidence than in B[a]P-treated wild-type and heterozygous mice. Our results show for the first time that XPA-deficient mice also displayed an increased sensitivity to developing tumors other than tumors of the skin.

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Citations

Feb 25, 2000·Mutation Research·J Vijg
Nov 6, 2003·Toxicology·Susan W P Wijnhoven, Harry van Steeg
May 9, 2006·Antioxidants & Redox Signaling·Yousin Suh, Jan Vijg
Oct 19, 2007·Nucleic Acids Research·Ahmad R HeydariArlan Richardson
Jul 1, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Petra C E van KesterenMirjam Luijten
Aug 15, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Joost van DelftJos Kleinjans
Apr 25, 2000·Molecular and Cellular Biology·C A Torres-RamosS Prakash
Dec 15, 2010·Blood·Grégory ChevillardVolker Blank
Oct 13, 2007·Mutation Research·Dhrubajyoti ChakravartiEleanor G Rogan
May 26, 2005·Mutation Research·Esther M HoogervorstAnnemieke de Vries
Dec 24, 1998·Toxicologic Pathology·H van SteegC F van Kreijl
Jun 24, 2004·Toxicologic Pathology·Jerrold M Ward, Deborah E Devor-Henneman
Dec 5, 1998·The Journal of Biological Chemistry·S ProstD J Harrison

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