PMID: 7536465Mar 1, 1995Paper

Spontaneous loss of Ph chromosome with maintenance of clonal hemopoiesis in an untreated patient with myeloproliferative disease and a long survival

Genes, Chromosomes & Cancer
M LuppiG Torelli

Abstract

The unusual case of myeloproliferative disease described here is characterized by the following features: (1) a clinically completely silent course for 11 years without splenomegaly, marrow fibrosis, or cellular morphologic alterations; (2) the presence, at the onset, of a Philadelphia (Ph) chromosome without DNA breakpoints in the M-bcr region; (3) the spontaneous loss of detectable Ph-positive cells, 5 years after the first finding of leukocytosis, in the absence of any therapy; (4) the maintenance of the clonal nature of hematopoiesis, as revealed by the PGK X-linked inactivation pattern, in the absence of the Ph chromosome; and (5) a biphasic trend in the levels of leukocytes, red cells, and platelets during the years of observation.

References

Jan 1, 1992·British Journal of Haematology·G J Morgan, L M Wiedemann
Aug 1, 1989·British Journal of Haematology·C FeganJ A Whittaker
Feb 1, 1989·British Journal of Haematology·M A WodzinskiA C Lawrence
Oct 13, 1988·The New England Journal of Medicine·R KurzrockM Talpaz
Mar 1, 1986·American Journal of Clinical Pathology·C Di DonatoA C Plancher
Jun 1, 1984·British Journal of Haematology·C R SingerA S Douglas

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Citations

Jan 1, 1997·American Journal of Hematology·E BandieriG Torelli

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