PMID: 8601563Jan 1, 1996Paper

Spontaneous lung metastases in a human lung tumor xenograft: a new experimental model

Journal of Cancer Research and Clinical Oncology
C CortiF Zunino

Abstract

The cell line NIH-H460, derived from a human large-cell carcinoma of the lung, because metastatic in the lung of athymic mice after S.C. injection. Using serial S.C. passages of the lung metastasis, a cell line was selected, H460M, which was characterized by an increased metastatic potential compared to the parental cells after s.c. (Spontaneous metastases) or i.v. injection (experimental metastases). For the high frequency of lung metastases in the mouse and the short time required to develop metastatic foci, the H460M cells transplanted in nude mice represent a unique preclinical model for biological and therapeutic studies. The paper describes the growth and some biological properties (invasion and migration capability, membrane profile) of this experimental in vivo model.

References

Jan 1, 1992·Journal of the National Cancer Institute·D W MulvinM R Johnston
Jul 15, 1987·International Journal of Cancer. Journal International Du Cancer·N M VarkiJ E Miller
Jan 1, 1984·Cancer Metastasis Reviews·F E Sharkey, J Fogh
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Citations

Jun 23, 2010·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Jung Sun YooKwang-Sup Soh
Dec 6, 2008·Journal of Translational Medicine·Qian XieGeorge F Vande Woude
Aug 29, 2003·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Catherine MaingonnatBertrand Delpech
Jan 25, 2002·International Journal of Cancer. Journal International Du Cancer·Sébastien ParisMaryam Diarra-Mehrpour
Aug 7, 2004·Matrix Biology : Journal of the International Society for Matrix Biology·Laurent DavidJean-Pierre Vannier
Apr 18, 2013·Biomaterials·Tanmoy SadhukhaJayanth Panyam
Oct 3, 2007·The Journal of Pharmacology and Experimental Therapeutics·Rosanna SupinoFranco Zunino
Sep 21, 2006·Molecular Cancer Therapeutics·Giuliana CassinelliFranco Zunino
Feb 26, 1999·Analytical Biochemistry·C MaingonnatB Delpech

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