Spontaneous Malignant Transformation of a Pilocytic Astrocytoma of Cerebellum: Case Report

Child Neurology Open
Joana CoelhoDuarte Salgado

Abstract

Pilocytic astrocytoma is a slowly growing neoplasia that represents the most frequent cerebral tumor in pediatric age. Malignant transformation is rare and it is usually related to previous radiotherapy. The authors describe a case of a spontaneous malignant transformation of a pilocytic astrocytoma. A 3-year-old boy was diagnosed with a cerebellar hemisphere tumor. He was submitted to a complete excision of the lesion, and histological findings were consistent with pilocytic astrocytoma. It was negative for p53. Twelve years later he presented with a local recurrence. Histopathological diagnosis was glioblastoma and it was positive for p53. Death from disease progression occurred 16 months after the diagnosis of glioblastoma. This case suggests that patients with pilocytic astrocytoma need closer follow-up and further genotypic studies in order to provide clues to clinical behavior. Such understanding can allow us to stratify treatment accordingly and to proceed to more aggressive treatment when necessary.

References

Jul 1, 1978·Journal of Neurosurgery·G M KleinmanE P Richardson
Jul 1, 1995·Journal of Neurosurgery·A GajjarL E Kun
Jun 26, 2001·Pediatric Neurosurgery·D C BowersK J Cohen
Oct 5, 2001·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·C H Rickert, W Paulus
Mar 4, 2003·Pediatric Radiology·Ester J van der WalMary Edwards-Brown
Feb 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alberto BroniscerChristine E Fuller
Apr 10, 2008·The Journal of Clinical Investigation·Stefan PfisterPeter Lichter
Oct 2, 2008·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Ekrem UnalLema Tavli
Jan 24, 2009·Cancer Biology & Therapy·Ibrahim QaddoumiAlberto Broniscer
Oct 21, 2009·Journal of Child Neurology·Angela J Sievert, Michael J Fisher
May 4, 2010·Journal of Neurosurgery. Pediatrics·Garrett K ZoellerDavid I Sandberg
May 11, 2010·World Neurosurgery·James L FrazierAlfredo Quinones-Hinojosa
May 13, 2010·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Dimitrios ParaskevopoulosPanagiotis Selviaridis
Jun 24, 2010·Neurocirugía·A Otero-RodríguezT Zamora-Martínez
Dec 24, 2010·Neuro-oncology·Gregory T ArmstrongE Brannon Morris
Jan 7, 2011·Journal of Oncology·Sanna-Maria HedeMikael S Lindström
Feb 26, 2011·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Benjamin J PrivettPatrick Lo
May 17, 2011·Journal of Pediatric Hematology/oncology·Katherine B PetersSridharan Gururangan
Jul 11, 2012·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·E WinogradS Constantini
Feb 27, 2013·Journal of Child Neurology·Zsila Sadighi, John Slopis
Jan 29, 2014·Journal of Pediatric Neurosciences·Sonam Kumar PruthiC K Ballal

❮ Previous
Next ❯

Citations

Aug 12, 2020·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Cameron M ErdmanLuke Tomycz
Apr 14, 2016·Future Oncology·Michael A GarciaDaphne A Haas-Kogan
Apr 29, 2020·Journal of Neuro-oncology·Maximilian J MairAnna S Berghoff

❮ Previous
Next ❯

Methods Mentioned

BETA
surgical resection

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.