"Spontaneous" medication-related osteonecrosis of the jaw; two case reports and a systematic review

Australian Dental Journal
A Khominsky, Mawt Lim

Abstract

Medication-related osteonecrosis of the jaw (MRONJ) is a severe adverse drug effect consisting of bone destruction of the maxilla and/or mandible. The most common precipitating event described in the literature is the extraction of a tooth followed by "spontaneous" occurrence with no clear predisposing event. Current studies are investigating methods of managing dental extractions in patients at risk of MRONJ; however, no studies to date examine the aetiology and management of "spontaneous" MRONJ. This paper describes two cases of "spontaneous" MRONJ seen at the Dental Unit in the Alfred Hospital and systematically reviews the current literature. No significant interactions (P > 0.05) were detected between variables: age, sex, bone disease, antiresorptive, antiresorptive duration, jaw, location and stage. "Spontaneous" cases were commonly associated with the mylohyoid ridge, palatal tori and other anatomical sites, and tended to occur in those generally considered at low risk of developing MRONJ. The review suggests that perhaps the term "spontaneous" is a misnomer and thorough history taking is critical in establishing a precipitating event.

References

Oct 1, 1995·Australian Dental Journal·Y H Seah
Feb 28, 2002·British Dental Journal·C Scully
Sep 11, 2003·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·J WangM A Pogrel
Sep 11, 2003·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Robert E Marx
Oct 26, 2005·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Robert E MarxVishtasb Broumand
Feb 20, 2007·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Tony MavrokokkiAlastair Goss
Jul 28, 2007·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Percival J HerbozoRamón L Torrealba
Nov 21, 2007·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Robert E MarxJuan J Ulloa
Apr 30, 2008·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Stephen L Engroff, Domenick Coletti
Aug 12, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M A DimopoulosA Bamias
Nov 20, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ashraf BadrosMeletios A Dimopoulos
Jul 28, 2009·Journal of Clinical Epidemiology·David MoherUNKNOWN PRISMA Group
Jul 28, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J W HongS-K Lim
Aug 19, 2009·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Vivek Thumbigere-MathDavid L Basi
Sep 24, 2009·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Joan C LoUNKNOWN Predicting Risk of Osteonecrosis of the Jaw with Oral Bisphosphonate Exposure (PROBE) Investigators
Nov 12, 2009·Scandinavian Journal of Urology and Nephrology·Ali HaidarLars Lund
Nov 21, 2009·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Yong-Dae KwonChristian Walter
May 4, 2010·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Sophie C C KuijpersJ P Richard van Merkesteyn
May 11, 2010·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Matteo ScolettaMarco Mozzati
Jun 29, 2010·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Sven OttoChristoph Pautke
Dec 18, 2010·International Journal of Oral and Maxillofacial Surgery·M ManfrediP Vescovi
Mar 24, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A M VandoneM Scoletta
Jul 26, 2011·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Masahiro UradeJinichi Fukuta
May 3, 2012·Medicina oral, patología oral y cirugía bucal·Márcio Diniz-FreitasPedro Diz-Dios
May 19, 2012·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Felice S O'Ryan, Joan C Lo
May 26, 2012·Australian Dental Journal·I HewsonF Bruscino-Raiola
Jul 31, 2012·International Journal of Oral and Maxillofacial Surgery·T YamazakiK Bessho
Sep 25, 2012·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Kenneth E FleisherRobert S Glickman
Feb 21, 2013·Indian Journal of Dental Research : Official Publication of Indian Society for Dental Research·Giuseppina CampisiGiuseppe Colella
Jun 1, 2013·Medicina oral, patología oral y cirugía bucal·Francesco BeninatiGiuseppe Ficarra
Aug 21, 2013·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Sarina E C Pichardo, J P Richard van Merkesteyn
Mar 20, 2014·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Herman VercruysseMaurice Y Mommaerts
Sep 23, 2014·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Salvatore L RuggieroFelice O'Ryan
Nov 22, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Aliya A KhanUNKNOWN International Task Force on Osteonecrosis of the Jaw
Apr 15, 2015·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Rodrigo Nascimento LopesFabio Abreu Alves
Nov 27, 2015·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Salvatore L Ruggiero, Nina Kohn
Aug 6, 2016·Journal of Pain & Palliative Care Pharmacotherapy·Tanja Fusi-Schmidhauser, Donata Bardelli
Jan 1, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A M VandoneM Scoletta

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