PMID: 8961371Oct 1, 1996Paper

Spontaneous metastasis, proliferation characteristics and radiation sensitivity of fractionated irradiation recurrent and unirradiated human xenografts

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
P HuangH D Suit

Abstract

Do tumor cells which survive high dose fractionated irradiation exhibit modified metastasis activity, proliferation kinetics, and/or radiation sensitivity? To address this question experimentally, we have studied three recurrent human tumor xenograft systems. Three models were derived from a soft tissue sarcoma (HSTS26T), a colon adenocarcinoma (HCT15), and a glioblastoma (HGL21) which had recurred after 90 Gy, 109 Gy, or 77.4 Gy administered in 30 equal doses, respectively. Their production of spontaneous metastasis and cell proliferation characteristics were studied in early generation xenografts in SCID mice, and were compared to those in their previously unirradiated counterparts. As a control, we have also studied each tumor as a post-surgical recurrence. Specimens from the irradiated recurrent and their unirradiated primary tumors were cultured in vitro and their radiation sensitivity determined by clonogenic assay. The three irradiated recurrent tumor systems retained the individual histological features of their unirradiated primary xenografts. A lower metastatic incidence was observed in two of the three irradiated recurrent tumor lines in comparison with their unirradiated control tumors and their surgical recurrent c...Continue Reading

Citations

Aug 9, 2007·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·C ThomasN Foray
Aug 23, 2001·Medical Hypotheses·C ThomasB Fertil
Mar 30, 2002·Annals of Surgical Oncology·Genc BashaFreddy Penninckx

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