PMID: 45101Jan 1, 1979

Spontaneous motility of isolated mesosalpinx-free isthmic and ampullar segments from human oviducts, and the influences of indomethacin and prostacyclin (PGI2)

International Journal of Fertility
A L GimenoM F Gimeno

Abstract

The spontaneous contractile activity of isolated mesosalpinx-deprived isthmic and ampullar segments from estrogen dominated human oviducts and the influences of indomethacin, prostaglandin F2-alpha, (PGF2-alpha), E1 (PGE1), E2 (PGE2) and prostacyclin (PGI2) on their motility, were explored. Indomethacin enhanced significantly the Isometric Developed Tension (I.D.T.) of the isthmic but not the ampullar region. On the other hand, a single and identical concentration (10(-6) M) of PGE1 and PGI2 depressed the ampulla whereas PGE2 and PGF2-alpha enhanced its contractions. In the isthmus, PGE1, PGE2, and PGF2-alpha augmented whereas PGI2 diminished the I.D.T. Dose-response curves of PGI2 demonstrated a dose-dependent depression of I.D.T. and contractile frequency of both ampullar and isthmic regions. Furthermore, in the isthmus PGI2 resulted in a biphasic action on resting basal tone (depressing at low and augmenting at high concentrations), whereas in the ampulla only a progressive dose-dependent decline, was observed. The results suggest that a prostaglandin with inhibitory capacity, presumably PGI2, may be synthesized by the human isthmus and play some role in the reduced spontaneous activity observed under estrogenic dominance.

Related Concepts

Animal Oviduct
Cell Motility
Depressed - Symptom
Osmosin
Fallopian Tubes
Flolan
Contraction (Finding)
Motility
Estrogenic
Isthmus of the Cingulate Gyrus

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Sexual Dimorphism in Neurodegeneration

There exist sex differences in neurodevelopmental and neurodegenerative disorders. For instance, multiple sclerosis is more common in women, whereas Parkinson’s disease is more common in men. Here is the latest research on sexual dimorphism in neurodegeneration

HLA Genetic Variation

HLA genetic variation has been found to confer risk for a wide variety of diseases. Identifying these associations and understanding their molecular mechanisms is ongoing and holds promise for the development of therapeutics. Find the latest research on HLA genetic variation here.

Super-resolution Microscopy

Super-resolution microscopy is the term commonly given to fluorescence microscopy techniques with resolutions that are not limited by the diffraction of light. Here are the latest discoveries pertaining to super-resolution microscopy.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

Brain Lower Grade Glioma

Low grade gliomas in the brain form from oligodendrocytes and astrocytes and are the slowest-growing glioma in adults. Discover the latest research on these brain tumors here.

CD4/CD8 Signaling

Cluster of differentiation 4 and 8 (CD8 and CD8) are glycoproteins founds on the surface of immune cells. Here is the latest research on their role in cell signaling pathways.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.