Spontaneous mutational correlations for life-history, morphological and behavioral characters in Caenorhabditis elegans

Genetics
Suzanne EstesPatrick C Phillips

Abstract

The pattern of mutational covariance among traits plays a central, but largely untested, role in many theories in evolutionary genetics. Here we estimate the pattern of phenotypic, environmental, and mutational correlations for a set of life-history, behavioral, and morphological traits using 67 self-fertilizing lines of Caenorhabditis elegans, each having independently experienced an average of 370 generations of spontaneous mutation accumulation. Bivariate relationships of mutational effects indicate the existence of extensive pleiotropy. We find that mutations may tend to produce manifold effects on suites of functionally related traits; however, our data do not support the idea of completely parcelated pleiotropy, in which functional units are separately affected by mutations. Positive net phenotypic and mutational correlations are common for life-history traits, with environmental correlations being comparatively smaller and of the same sign for most pairs of traits. Observed mutational correlations are shown to be higher than those produced by the chance accumulation of nonpleiotropic mutations in the same lines.

References

Jan 1, 1989·Annual Review of Genetics·N H Barton, M Turelli
Sep 21, 1984·Journal of Theoretical Biology·J M Cheverud
Mar 25, 1993·Nature·L Partridge, N H Barton
Jul 1, 1996·Genetics·D HouleM Lynch
Dec 16, 1998·Science·UNKNOWN C. elegans Sequencing Consortium
Dec 16, 1998·Science·C I Bargmann
Dec 2, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·E R Troemel
Jul 25, 2000·Heredity·B J Crespi
Sep 27, 2000·Evolution; International Journal of Organic Evolution·L L VassilievaM Lynch
Dec 7, 2000·Evolution; International Journal of Organic Evolution·A Poon, S P Otto
Oct 6, 2001·Science·J R Etterson, R G Shaw
Oct 30, 2001·Evolution; International Journal of Organic Evolution·C G KnightA M Leroi
Oct 26, 2002·Genetics·Ricardo B R AzevedoArmand M Leroi
Nov 27, 2002·Evolution; International Journal of Organic Evolution·Michael C WhitlockKevin Fowler
Jul 3, 2003·Evolution; International Journal of Organic Evolution·Suzanne Estes, Michael Lynch
Sep 25, 2003·Evolution; International Journal of Organic Evolution·Adam G JonesReinhard Bürger
Sep 25, 2003·Evolution; International Journal of Organic Evolution·Xu-Sheng Zhang, William G Hill
Sep 24, 2004·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·James M CheverudL Susan Pletscher
Apr 19, 2005·Genetics·Beverly C AjiePatrick C Phillips
Jun 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·R Lande
Nov 1, 1992·The American Naturalist·S J Arnold
Jul 1, 1985·Evolution; International Journal of Organic Evolution·Michael Lynch
May 1, 1985·Evolution; International Journal of Organic Evolution·Sara Via, Russell Lande
Dec 1, 1990·Evolution; International Journal of Organic Evolution·Gerald S WilkinsonLinda Partridge
Dec 1, 1997·Evolution; International Journal of Organic Evolution·James M CheverudDuncan J Irschick
Jun 1, 1998·Evolution; International Journal of Organic Evolution·Michael LynchMatthew Giorgianni
Jun 1, 1996·Evolution; International Journal of Organic Evolution·Günter P Wagner, Lee Altenberg
Oct 1, 1999·Evolution; International Journal of Organic Evolution·Hong-Wen DengGleb Haynatzki

❮ Previous
Next ❯

Citations

Oct 7, 2011·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Jennifer L AndersonPatrick C Phillips
Mar 18, 2009·Molecular Biology and Evolution·Asher D CutterRosalind L Murray
Sep 11, 2010·Journal of Biomedical Science·Hye Min KimDong Hee Lee
Jun 8, 2011·BMC Evolutionary Biology·Jennifer L AndersonPatrick C Phillips
May 19, 2009·BMC Ecology·Daniel MuschiolWalter Traunspurger
Mar 20, 2010·PLoS Genetics·Christian BraendleMarie-Anne Félix
Apr 19, 2005·Genetics·Beverly C AjiePatrick C Phillips
Mar 7, 2007·Genetics·Cortland K GriswoldRichard Gomulkiewicz
May 8, 2007·Genetics·Dejerianne OstrowCharles F Baer
Feb 1, 2007·Evolution; International Journal of Organic Evolution·Suzanne Estes, Patrick C Phillips
Jan 17, 2014·Proceedings. Biological Sciences·Jeremy C Gray, Asher D Cutter
Feb 15, 2008·The American Naturalist·Agnieszka DoroszukJan E Kammenga
Sep 22, 2015·Evolution; International Journal of Organic Evolution·Julie M ColletKatrina McGuigan
Jun 9, 2009·Trends in Ecology & Evolution·David C LahtiSusan A Foster
May 12, 2007·Evolution; International Journal of Organic Evolution·Mattieu Bégin, Daniel J Schoen
Apr 8, 2006·Molecular Ecology·Katrina McGuigan
Feb 20, 2007·Journal of Evolutionary Biology·D A Roff, D J Fairbairn
Apr 19, 2007·Evolution; International Journal of Organic Evolution·Adam G JonesReinhard Bürger
May 16, 2012·Annals of the New York Academy of Sciences·David H ReedTorsten N Kristensen
Jul 28, 2011·Evolution; International Journal of Organic Evolution·Suzanne EstesDee R Denver
Apr 5, 2013·Evolution; International Journal of Organic Evolution·Katrina McGuigan, Mark W Blows
Oct 5, 2011·Evolution; International Journal of Organic Evolution·Katrina McGuiganMark W Blows
Apr 23, 2015·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Alexei A MaklakovUrban Friberg
Jul 29, 2016·Evolution; International Journal of Organic Evolution·Sarah K DaviesCharles F Baer
Sep 30, 2016·Molecular Biology and Evolution·Robert PolsterFrédéric Guillaume
Apr 29, 2005·Nature Genetics·Greg Gibson
Nov 17, 2017·Ecology Letters·Martino E MalerbaDustin J Marshall
Jul 19, 2019·Evolution; International Journal of Organic Evolution·Chang S HanNiels J Dingemanse
Aug 31, 2018·G3 : Genes - Genomes - Genetics·Sarah EberleLeigh C Latta
Jul 30, 2017·Evolution; International Journal of Organic Evolution·Jobran Chebib, Frédéric Guillaume
Sep 9, 2017·Evolution; International Journal of Organic Evolution·Katrina McGuigan, Ernest Aw
Aug 16, 2018·Frontiers in Molecular Biosciences·Lindsay M JohnsonCharles F Baer
Mar 15, 2019·BMC Evolutionary Biology·Gavin C WoodruffPatrick C Phillips
Apr 17, 2021·Nature Ecology & Evolution·Erik I SvenssonAnna Runemark

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.