Spontaneous neuronal burst discharges as dependent and independent variables in the maturation of cerebral cortex tissue cultured in vitro: a review of activity-dependent studies in live 'model' systems for the development of intrinsically generated bioelectric slow-wave sleep patterns

Brain Research Reviews
M A Corner

Abstract

A survey is presented of recent experiments which utilize spontaneous neuronal spike trains as dependent and/or independent variables in developing cerebral cortex cultures when synaptic transmission is interfered with for varying periods of time. Special attention is given to current difficulties in selecting suitable preparations for carrying out biologically relevant developmental studies, and in applying spike-train analysis methods with sufficient resolution to detect activity-dependent age and treatment effects. A hierarchy of synchronized nested burst discharges which approximate early slow-wave sleep patterns in the intact organism is established as a stable basis for isolated cortex function. The complexity of reported long- and short-term homeostatic responses to experimental interference with synaptic transmission is reviewed, and the crucial role played by intrinsically generated bioelectric activity in the maturation of cortical networks is emphasized.

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Citations

Jul 9, 2011·Cellular and Molecular Neurobiology·Irina I StoyanovaJoost le Feber
Jun 18, 2010·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·James E JanMichael B Wasdell
Jun 18, 2010·Neural Networks : the Official Journal of the International Neural Network Society·Luca Leonardo BolognaMichela Chiappalone
Oct 9, 2015·Sleep Medicine Reviews·James M KruegerSandip Roy
Sep 30, 2015·Scientific Reports·Arthur BikbaevMartin Heine
May 9, 2013·The European Journal of Neuroscience·James M KruegerDaniel J Buysse
Sep 18, 2010·The European Journal of Neuroscience·Jyh-Jang SunHeiko J Luhmann
May 1, 2014·Journal of African Earth Sciences·Wolf Uwe Reimold, Christian Koeberl
Sep 10, 2014·Proceedings of the National Academy of Sciences of the United States of America·Anna R MooreSrdjan D Antic
Jul 28, 2016·Frontiers in Neuroscience·Ilaria ColombiMichela Chiappalone
May 16, 2014·Physical Biology·Joost le FeberMichela Chiappalone
Feb 12, 2021·Brain, Behavior, and Immunity·Cheryl Dykstra-AielloJames M Krueger
Apr 20, 2021·Frontiers in Cell and Developmental Biology·Irina Stoyanova, David Lutz

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