PMID: 9164632Apr 1, 1997Paper

Spontaneous or interferon-gamma-induced T-cell infiltration, HLA-DR and ICAM-1 expression in genitoanal warts are associated with TH1 or mixed TH1/TH2 cytokine mRNA expression profiles

Archives of Dermatological Research
A GrasseggerR M Höpfl

Abstract

The purpose of the study was to investigate the cytokine gene expression patterns and immunohistochemical characteristics of genitoanal warts in order to obtain a clue as to the immunological mechanisms possibly relevant for wart regression or persistence. We analysed surgically removed warts from 11 patients, 2 of whom were immunosuppressed. Lesions of five of the nine otherwise healthy individuals were additionally treated with intralesional interferon-gamma (IFN gamma) prior to surgery. Invasion of CD4+ T cells into the papillomas and HLA-DR and ICAM-1 expression on keratinocytes were found in two otherwise healthy patients and were intensified by intralesional IFN gamma in four of five patients. The mRNA expression patterns in seven of eight non-recurrent warts were compatible with a predominant TH1 or mixed TH1/TH2 cytokine profile. In contrast, in recalcitrant warts of three patients (one healthy, two immunocompromised) histological signs of immunore-activity and TH1-like cytokine mRNA expression were not detected. In recurrent warts of a renal transplant patient, IL-4 and IL-5 mRNA expression was repeatedly found suggesting a predominant TH2 response. In conclusion, immunoreactivity to genitoanal warts such as T-cell inf...Continue Reading

Citations

May 31, 2007·Clinical and Experimental Dermatology·J TaoY-T Tu
Mar 28, 2008·Immunological Reviews·Chien-Fu HungRichard Roden
Aug 24, 1999·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·P C Maciag, L L Villa
Apr 26, 2008·Journal of Korean Medical Science·Ja Kyung KuYoung Min Park
Jun 27, 2019·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Dietrich AbeckTilo Biedermann
Jun 27, 2019·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Dietrich AbeckTilo Biedermann
Apr 3, 2001·Journal of Cutaneous Medicine and Surgery·J SeversonS K Tyring
Oct 15, 2013·Journal of the European Academy of Dermatology and Venereology : JEADV·K AydoganB Oral
Nov 20, 2004·Clinical and Experimental Dermatology·A Grassegger, R Höpfl
Jun 22, 2000·Journal of the American Academy of Dermatology·S K Tyring

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