Spontaneous oscillatory contraction (SPOC) in cardiomyocytes

Biophysics Reviews
Tatsuya KagemotoShin'ichi Ishiwata

Abstract

SPOC (spontaneous oscillatory contraction) is a characteristic state of the contractile system of striated (skeletal and cardiac) muscle that exists between the states of relaxation and contraction. For example, Ca-SPOCs occur at physiological Ca2+ levels (pCa ∼6.0), whereas ADP-SPOC occurs in the virtual absence of Ca2+ (pCa ≥ 8; relaxing conditions in the presence of MgATP), but in the presence of inorganic phosphate (Pi) and a high concentration of MgADP. The concentration of Mg-ADP necessary for SPOC is nearly equal to or greater than the MgATP concentration for cardiac muscle and is several times higher for skeletal muscle. Thus, the cellular conditions for SPOC are broader in cardiac muscle than in skeletal muscle. During these SPOCs, each sarcomere in a myofibril undergoes length oscillation that has a saw-tooth waveform consisting of a rapid lengthening and a slow shortening phase. The lengthening phase of one half of a sarcomere is transmitted to the adjacent half of the sarcomere successively, forming a propagating wave (termed a SPOC wave). The SPOC waves are synchronized across the cardiomyocytes resulting in a visible wave of successive contractions and relaxations termed the SPOC wave. Experimentally, the SPOC per...Continue Reading

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Citations

Jul 8, 2018·Circulation. Heart Failure·Tatsuya KagemotoShin'ichi Ishiwata
Mar 22, 2016·Biophysics Reviews·Sean LalCristobal Dos Remedios
Jun 27, 2017·Reports on Progress in Physics·M Caruel, L Truskinovsky
Feb 3, 2021·Micromachines·Leslie DonoghuePalaniappan Sethu
Jun 13, 2021·Nature Communications·Andrew T MeekMalte C Gather

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