PMID: 9537056Jan 1, 1980Paper

Spontaneous plaque-forming human lymphocytes detected with the protein-A plaque assay

Scandinavian Journal of Immunology
A Freijd, T Kunori

Abstract

A sizable proportion of fresh human blood and adenoid lymphocytes were found to produce antibodies when tested in the protein-A plaque assay of Gronowicz et al. Plaque formation was not caused by release of passively adsorbed immunoglobulin but depended on active immunoglobulin secretion. We have investigated optimal conditions for plaque formation in this test system. Good reproducibility is obtained only if cells to be tested are kept in the cold before assay, since the antibody-forming capacity of these cells is rapidly exhausted at temperatures above 2 degrees C. In blood lymphocytes the number of IgA-producing cells exceeds those of IgG and IgM, whereas in the adenoid IgG plaque-forming cells dominate. Studies on the use of this method for the monitoring of immune responses are in progress.

References

Jan 1, 1979·Scandinavian Journal of Immunology·A G Bird, S Britton
Jan 1, 1979·Scandinavian Journal of Immunology·K H RobèrtE Möller
Jan 1, 1978·Scandinavian Journal of Immunology·D PetterssonG Holm
Aug 1, 1976·European Journal of Immunology·E GronowiczF Melchers
Sep 1, 1975·Scandinavian Journal of Immunology·S AhlstedtR M Goldblum
Jul 1, 1971·The Journal of Experimental Medicine·S W Craig, J J Cebra
Apr 1, 1964·The Journal of Experimental Medicine·J S INGRAHAM, A BUSSARD
Apr 26, 1963·Science·N K Jerne, A A Nordin

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Citations

May 31, 1985·Mechanisms of Ageing and Development·S AntonaciL Bonomo
Nov 1, 1987·Mechanisms of Ageing and Development·S AntonaciL Bonomo
Jul 1, 1984·Veterinary Immunology and Immunopathology·P J FelsburgP F Jezyk
Apr 1, 1996·Journal of Gastroenterology·T KunoriS Asano
Jan 1, 1980·Scandinavian Journal of Immunology·C I Smith, L Hammarström
Nov 1, 1985·Scandinavian Journal of Immunology·N G Al-TawilE Möller
Nov 1, 1987·Scandinavian Journal of Immunology·O RingdénJ Tollemar
Dec 16, 1983·Journal of Immunological Methods·N R Ling

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