PMID: 7538045Jun 1, 1995Paper

Spontaneous pneumothorax complicating chemotherapy for metastatic seminoma. A case report and a review of the literature

Cancer
M E SteinA Kuten

Abstract

Spontaneous pneumothorax complicating chemotherapy has been reported mainly in metastatic sarcoma, particularly of the osteogenic type. The main factor in the etiology of spontaneous pneumothorax could be related to tumor lysis and/or rapid rupture of chemosensitive peripheral or subpleural metastasis into the pleural cavity, thus leading to a bronchopleural fistula. A 49-year-old patient in whom spontaneous pneumothorax developed after successful chemotherapy for metastatic seminoma is described. On chest tube drainage, the lung reexpanded rapidly and the patient became clinically and radiographically symptom free. To the authors' knowledge, this is only the second case of spontaneous pneumothorax complicating chemotherapy-induced rapid regression of lung and mediastinal metastases in patients with seminoma. Spontaneous pneumothorax should be included in the spectrum of chemotherapy-related side effects in chemosensitive solid tumors with lung metastases.

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Citations

Dec 7, 2002·Hematological Oncology·C S ChimY L Kwong
Oct 26, 2005·International Journal of Clinical Oncology·Yoshihiro KobashiMikio Oka
Jan 16, 2002·The Annals of Thoracic Surgery·G Le GarffP Delaval
Jan 1, 1997·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·F M LaurencetP Y Dietrich
Jun 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·R M AlaniC B Shifflett
Sep 27, 2000·Clinical Oncology : a Journal of the Royal College of Radiologists·E R PlummerJ T Roberts

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