Spontaneous portosystemic shunt: relationship to spontaneous encephalopathy and gastrointestinal hemorrhage

Digestive Diseases and Sciences
K C LamT B Reynolds

Abstract

This study examined the effect of large spontaneous portosystemic shunts on the incidence of variceal hemorrhage and hepatic encephalopathy. Twenty cases of chronic liver disease with large spontaneous shunts were compared with a group of patients with liver disease and with Cruveilhier-Baumgarten (C-B) murmurs and with a control group having liver disease and absence of large shunts on angiography. Gastrointestinal hemorrhage was present in similar proportions of patients in the three groups. Hepatic encephalopathy occurred more frequently in the spontaneous shunt group and C-B murmur group. The encephalopathy was spontaneous in 12 of 14 patients with large natural shunts whereas it was precipitated by events such as gastrointestinal bleeding, diuretics, or infection in 14 of 15 of the patients with C-B murmur and five of the seven controls. Therefore, spontaneous portosystemic shunts do not protect against gastrointestinal hemorrhage and are associated with an increased risk of spontaneous hepatic encephalopathy.

Citations

May 1, 2020·World Journal of Gastroenterology : WJG·Silvia NardelliLorenzo Ridola
Apr 24, 2001·The American Journal of Gastroenterology·Z HassounG Pomier-Layrargues
Jun 9, 2018·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Tsuyoshi IshikawaIsao Sakaida
Feb 27, 2019·Journal of Clinical Gastroenterology·Lauren Shreve, Edward Wolfgang Lee
Dec 25, 2019·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Eduardo A RodriguezHugo E Vargas
Jul 1, 1988·Journal of Clinical Ultrasound : JCU·T H ShawkerM R Filling-Katz
Feb 13, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Wim LalemanUNKNOWN EASL-CLIF-Consortium
Jun 15, 2018·The American Journal of Gastroenterology·Edward Wolfgang LeeStephen T Kee
Mar 28, 2020·United European Gastroenterology Journal·Lorenzo RidolaSilvia Nardelli
May 31, 2008·The American Journal of Gastroenterology·Praveen SharmaShiv K Sarin
Oct 16, 2015·Gastroenterology Report·Saleh ElwirThomas Riley
Jun 29, 2017·AJR. American Journal of Roentgenology·Tsuyoshi IshikawaIsao Sakaida
Mar 13, 2016·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Amanda M LynnMichael D Leise
Jul 1, 1984·The British Journal of Radiology·K TakayasuK Okuda
Feb 1, 1990·Cardiovascular and Interventional Radiology·R B RafalJ A Markisz
Sep 6, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Robin GreinertCristina Ripoll
Oct 17, 2020·Therapeutic Advances in Gastroenterology·Judit Vidal-GonzálezJoan Genescà
Jan 30, 2021·Journal of Translational Internal Medicine·Lorenzo RidolaOliviero Riggio
Aug 3, 2021·JHEP Reports : Innovation in Hepatology·Yasuko Iwakiri, Jonel Trebicka

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