Abstract
Spontaneous pregnancies and live births are rarely reported after haematopoietic stem cell transplant (HSCT). We report spontaneous pregnancy outcomes of sexually active female survivors of childhood allogeneic HSCT, to provide more data for future counselling. Retrospective review of all female survivors of childhood haematological malignancies who had allogeneic HSCT at the Royal Children Hospital between 1985 and 2011. Data were retrieved from medical records, updated from treating haematologist or endocrinologist, and were cross-referenced with self-reported questionnaires. Female survivors who were sexually inactive were excluded from analysis. Six of 37 (16.2%) female survivors reported spontaneous pregnancies resulting in 8 live births. Amongst 22 women who received total body irradiation (n = 21) ± cranial irradiation or isolated cranial irradiation (n = 1), and high-dose cyclophosphamide, three reported pregnancy resulting in live births (14%), whilst three of 15 women who received chemotherapy alone had pregnancy with live births (20%). Our current finding, albeit a small sample size, reinforces the importance of counselling female survivors of HSCT about the possibility of spontaneous pregnancy occurring despite docu...Continue Reading
References
Apr 1, 1980·The British Journal of Radiology·P Ash
Jul 1, 1993·Environmental Health Perspectives·A L Ogilvy-Stuart, S M Shalet
Aug 11, 2001·Lancet·N SaloojaUNKNOWN Late Effects Working Party of the European Group for Blood and Marrow Transplantation
Dec 1, 2001·Human Reproduction Update·D Meirow, D Nugent
May 6, 2004·Pediatric Blood & Cancer·Julianne ByrneLeslie L Robison
Apr 11, 2006·Bone Marrow Transplantation·A CarterS Bhatia
Jul 5, 2006·Journal of the National Cancer Institute·Charles A SklarLeslie L Robison
Mar 25, 2009·International Journal of Radiation Oncology, Biology, Physics·Jennifer Y Wo, Akila N Viswanathan
Apr 15, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daniel M GreenLeslie L Robison
Jan 30, 2010·PloS One·W Hamish B Wallace, Thomas W Kelsey
Jul 28, 2010·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Alison W LorenNavneet S Majhail
Jul 17, 2013·The Lancet Oncology·Sara E BartonLisa Diller
Nov 2, 2013·European Journal of Endocrinology·A VatanenK Jahnukainen
Nov 15, 2016·Bone Marrow Transplantation·A WędrychowiczJ Starzyk
Feb 27, 2018·Reproductive Biomedicine Online·Anne-Sofie KorsholmHelene Westring Hvidman
Mar 9, 2018·The Journal of Obstetrics and Gynaecology Research·Akira IwaseFumitaka Kikkawa
Sep 23, 2018·Bone Marrow Transplantation·Mari WilhelmssonUNKNOWN Nordic Society of Pediatric Hematology and Oncology (NOPHO)