Spontaneous reactivation of hepatitis B virus with S gene mutations in an elderly patient with diabetic nephropathy.

Clinical Journal of Gastroenterology
Noriyuki ObaraAtsushi Masamune

Abstract

Generally, reactivation of hepatitis B virus (HBV) infection is induced by the administration of immunosuppressants or anticancer agents, but reactivation without such drugs has rarely been reported. Here we report an elder case with spontaneous reactivation of HBV replication accompanied by hepatitis B surface antigen (HBsAg) mutations. A 69-year-old man with a history of diabetes mellitus and chronic kidney disease (CKD) was found to be positive for HBsAg (0.072 IU/ml) in June 2018. In May 2019, marked hepatic dysfunction and increased HBsAg (2533.2 IU/ml) were observed when he visited the hospital due to diarrhea and worsening of CKD. At that time, hepatitis B surface antibody (HBsAb) was positive (268.9 mIU/ml) and HBV DNA was 6.0 log IU/ml. After treatment with entecavir, HBV DNA and HBsAg rapidly decreased. Full-genome HBV sequence analysis revealed that the patient was infected with HBV of subgenotype B1 and it had an "a" determinant mutation M133L in the S gene coding HBsAg. Notably, both HBsAg and HBsAb were positive at the time of HBV reactivation, suggesting that the HBV with these mutations escaped from neutralization by HBsAb. This case suggests that immune escape mutations could play an important role in spontaneo...Continue Reading

References

Aug 11, 1990·Lancet·W F CarmanH C Thomas
Jan 28, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Winnie Yeo, Philip J Johnson
Feb 23, 2008·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Jun InoueTooru Shimosegawa
Apr 29, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jay H Hoofnagle
May 8, 2014·Journal of Hepatology·Teresa PollicinoGiovanni Raimondo
Nov 25, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Romina SalpiniValentina Svicher
Dec 17, 2014·Journal of Infection in Developing Countries·Haimanti BhattacharyaAttayur Purushothaman Sugunan
Jan 23, 2015·Journal of Medical Virology·Hiroshi KamitsukasaHiroaki Okamoto
Apr 17, 2016·Journal of Hepatology·Shuping Tong, Peter Revill
Apr 25, 2017·Nature Reviews. Nephrology·Carmine ZoccaliUNKNOWN European Renal and Cardiovascular Medicine (EURECA-m) Working Group of the European Renal Association – European Dialysis Tr

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of the National Comprehensive Cancer Network : JNCCN
Bhumsuk KeamJung-Hwan Yoon
Hepatology Research : the Official Journal of the Japan Society of Hepatology
Makoto OketaniHirohito Tsubouchi
© 2022 Meta ULC. All rights reserved