PMID: 3762173Sep 1, 1986Paper

Spontaneous regional lymph node metastases of three variants of the B16 melanoma: relationship to primary tumor size and pulmonary metastases

Journal of Surgical Oncology
S David NathansonM Lee

Abstract

We studied the patterns of spontaneous regional lymph node metastases of three variants (F1, F10, and BL6) of the B16 melanoma in C57BL/6 mice and related the incidence to primary tumor size and pulmonary metastases. The incidence of regional lymph node and pulmonary metastases correlated with increasing primary tumor size (p less than or equal to 0.0001). The incidence of pulmonary metastases in mice whose regional lymph nodes did not contain tumor also correlated with increasing primary tumor size (p less than or equal to 0.0001). This propensity for direct hematogenous spread was more apparent in BL6 tumors than in F1 and F10 tumors (p less than or equal to 0.0001). BL6 tumors also metastasized to regional nodes at smaller primary tumor sizes (p less than or equal to 0.04). Heterogeneous variants that metastasize earlier to regional lymphatic and hematogenous sites dictates the natural history of the primary tumor. Whether prophylactic lymphadenectomy for melanomas is therapeutic may depend on dissemination-related phenotypic characteristics.

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Citations

Jan 1, 1993·Clinical & Experimental Metastasis·S D NathansonM Lee
May 11, 2011·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Elliot L ServaisPrasad S Adusumilli
Feb 12, 2008·Clinical & Experimental Metastasis·Robert B RebhunJeffrey E Gershenwald
Jun 27, 2003·Breast Cancer Research and Treatment·Karen LibyNira Ben-Jonathan
Feb 28, 2015·Nature Communications·Duygu SagCatherine C Hedrick
Mar 26, 2011·The American Journal of Pathology·Kiarash KhosrotehraniSelim Aractingi
Dec 3, 2014·Seminars in Cell & Developmental Biology·S D NathansonK Rosso
Jul 23, 2003·Cancer·S David Nathanson
Feb 26, 1999·The Journal of Urology·H KonakaM Namiki
Jan 1, 1994·Pediatric Hematology and Oncology·F Tzortzatou-Stathopoulou
May 1, 1989·Journal of Surgical Oncology·S D NathansonM Lee
May 1, 1995·Cancer Immunology, Immunotherapy : CII·D ShrayerH Wanebo
Aug 5, 2020·Toxicology Mechanisms and Methods·Ludiana Cardoso da Silva CansianFrancisco Filipak Neto
Mar 1, 1997·Annals of Surgical Oncology·S D NathansonS Havstad
Jan 5, 2002·Annals of Surgical Oncology·S D NathansonJ Ferrara
Mar 1, 1997·Clinical and Experimental Dermatology·S Retsas
Apr 11, 2019·Molecular Pharmaceutics·Barbara AlbertiniNathalie Wauthoz

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