Spontaneous regression in an ulcerated CK7 positive Merkel cell carcinoma

Indian Journal of Dermatology, Venereology and Leprology
Anza KhaderKarumathil Puthiaveetil Aravindan

Abstract

Merkel cell carcinoma is an aggressive and frequently lethal tumor of the elderly, associated with sun exposure and immunosuppression which is less common in the dark-skinned. We report the case of a 40-year-old woman who presented with multiple slowly progressive, mildly itchy ulcerated plaques of size ranging from 2 × 3 cm to 5 × 7 cm on the left knee of 1 year duration. Skin biopsy showed diffuse dermal infiltration by small round cells with molding of cells and lymphocyte infiltration. The cells stained positive for cytokeratin (CK) 20, CK7, neuron-specific enolase, and chromogranin. The skin lesions underwent spontaneous regression within 1 month of skin biopsy and have not recurred during the past 2 years. The immune mechanisms triggered by biopsy possibly explain the spontaneous regression.

References

Apr 12, 2005·European Journal of Cell Biology·Ingrid MollRoland Moll
Nov 2, 2007·The Journal of Dermatology·Hidemichi KuboTakuro Kanekura
Feb 19, 2008·Journal of the American Academy of Dermatology·Michelle HeathPaul Nghiem
Mar 28, 2008·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Antonio Giovanni RichettaStefano Calvieri
Jun 1, 2013·Indian Journal of Dermatology·Enzo ErrichettiFrancesco Ricciuti
Nov 13, 2013·Cancers·Pierre L Triozzi, Anthony P Fernandez

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Citations

Sep 22, 2018·Dermatologic Therapy·Gorkem TurkkanFunda Ustun
Dec 7, 2019·The American Journal of Dermatopathology·Angel Fernandez-FloresEduardo Fonseca
Mar 27, 2021·Indian Dermatology Online Journal·Gautam K SinghNagendra Singh Beniwal

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