Spontaneous Regression of Intravascular Large B-Cell Lymphoma and Apoptosis of Lymphoma Cells: A Case Report

Journal of Clinical and Experimental Hematopathology : JCEH
Tsutomu TakahashiJunji Suzumiya

Abstract

A 61-year-old Japanese woman presented with hemophagocytic syndrome (HPS) and suffered from intravascular large B-cell lymphoma (IVLBCL). After a few days of supportive care, her condition improved without any anti-cancer drugs or steroids. She experienced recurrences of HPS at 15 mon and 21 mon after first presentation, but lymphoma cells were not observed. Relapse of IVLBCL with pulmonary involvement occurred 27 mon after first presentation. She underwent R-CHOP therapy followed by autologous stem cell transplantation. She is currently alive and without lymphoma. Immunostaining by anti-ssDNA suggested that spontaneous regression may have been due to apoptosis of the lymphoma cells.

References

Jan 1, 1981·Journal of Surgical Oncology·W H Cole
Dec 6, 1984·The New England Journal of Medicine·S J Horning, S A Rosenberg
May 15, 1980·Cancer·H H GattikerD A Galton
Dec 24, 2003·Pediatric Surgery International·Eiso HiyamaTakashi Yokoyama
Jun 11, 2004·Pathology International·Kuniko IiharaYasuko Hirabayashi
May 19, 2007·Journal of Clinical and Experimental Hematopathology : JCEH·Rokuo AbeMasafumi Abe
Aug 7, 2007·International Journal of Hematology·Eiichi IshiiKeisei Kawa
May 29, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kazuyuki ShimadaTomohiro Kinoshita
Jul 15, 2009·Bone Marrow Transplantation·A NumataUNKNOWN Fukuoka Blood and Marrow Transplantation Group
Nov 26, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tsuguo IwataniKenichi Ohashi

❮ Previous
Next ❯

Citations

Apr 20, 2016·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Gelsomina MansuetoChiara Mignogna
Mar 29, 2019·Journal of Clinical and Experimental Hematopathology : JCEH·Yasuhiro TanakaKoichi Ohshima
Dec 12, 2018·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Marc DinkinAlexander E Merkler
Feb 3, 2019·Journal of Medical Case Reports·J SnijderG Rivero
Oct 17, 2020·Clinical Lymphoma, Myeloma & Leukemia·Lauren M StanoszekAnamarija M Perry
Jul 2, 2021·Journal of Clinical and Experimental Hematopathology : JCEH·Yoshiki FurukawaNorio Komatsu

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis