Spontaneous regression of lung metastasis in the absence of tumor necrosis factor receptor p55

International Journal of Cancer. Journal International Du Cancer
Yoshiharu TomitaNaofumi Mukaida

Abstract

In order to clarify the roles of tumor necrosis factor (TNF)-alpha in lung metastasis, we injected Renca cells intravenously into TNF receptor p55-deficient (TNF-Rp55 KO) and wild-type (WT) mice. Microscopic and macroscopic metastasis foci appeared in lungs at 7 and 14 days after the tumor injection, respectively. Moreover, metastasis foci expanded at similar rates in both WT and TNF-Rp55 KO mice until 21 days, and lungs were occupied with metastasis foci. However, later than 21 days after the injection, metastasis foci spontaneously regressed in TNF-Rp55 KO mice, whereas WT mice exhibited a progressive growth of metastasis foci. Moreover, metastasis foci remained reduced sizes in TNF-Rp55 KO mice even at 26 days, when all WT mice died with lungs filled with metastasis foci. Later than 21 days after the tumor injection, the number of apoptotic tumor cells was increased in TNF-Rp55 KO mice. In contrast, neovascularization was less evident in TNF-Rp55 KO than WT mice, with depressed hepatocyte growth factor (HGF) gene in TNF-Rp55 KO mice at 21 days after the tumor injection. Thus, TNF-Rp55-mediated signals can maintain tumor neovascularization at least partly by inducing HGF expression, and eventually support lung metastasis proc...Continue Reading

References

Oct 25, 1991·Proceedings of the National Academy of Sciences of the United States of America·L A TartagliaD V Goeddel
Apr 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·M LewisD V Goeddel
Jan 1, 1990·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S T MalikF R Balkwill
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M Fràter-SchröderP Böhlen
Mar 16, 1995·International Journal of Cancer. Journal International Du Cancer·P OroszD N Männel
May 1, 1993·The Journal of Experimental Medicine·P OroszD N Männel
Jun 27, 1996·The New England Journal of Medicine·F Bazzoni, B Beutler
Feb 24, 2000·The Journal of Pathology·F W OrrD M Nance
Sep 23, 2000·Nature·P Carmeliet, R K Jain
Feb 15, 2001·Seminars in Cancer Biology·I Stamenkovic
May 11, 2002·Laboratory Investigation; a Journal of Technical Methods and Pathology·Kazuya KitamuraNaofumi Mukaida
Jan 25, 2003·Journal of Biochemistry and Molecular Biology·Jiuhong YuHyeong-Reh Choi Kim
Jan 17, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Neil SenzerNader Hanna
Feb 27, 2004·The New England Journal of Medicine·Bruce E SandsSander J van Deventer

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Citations

Dec 12, 2012·Journal of Clinical Immunology·Juliana Candido, Thorsten Hagemann
Nov 1, 2008·Cancer Gene Therapy·H J MauceriR R Weichselbaum
Apr 4, 2009·Nature Reviews. Cancer·Frances Balkwill
Sep 25, 2009·Molecular & Cellular Proteomics : MCP·Chris PlanqueEleftherios P Diamandis
Oct 29, 2008·Acta Pharmacologica Sinica·Xia Wang, Yong Lin
Jan 26, 2008·The Journal of Clinical Investigation·Boryana K PopivanovaNaofumi Mukaida
Sep 11, 2009·The Journal of Clinical Investigation·Kellie A CharlesThorsten Hagemann
Jul 16, 2013·International Journal of Molecular Sciences·Wulf Schneider-BrachertMartin Ehrenschwender
Oct 20, 2012·World Journal of Gastroenterology : WJG·Kunihiro HosonoAtsushi Nakajima
Feb 8, 2013·Diabetes/metabolism Research and Reviews·P MatafomeR Seiça
Nov 30, 2010·Biochimica Et Biophysica Acta·Pedro L Prieto-HontoriaMaría J Moreno-Aliaga
Feb 23, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yiling ZhaoPing Sun
Jan 21, 2010·British Journal of Cancer·Y Wu, B P Zhou
Mar 10, 2011·The American Journal of Gastroenterology·Gati A GoelBret Lashner
Dec 31, 2005·International Journal of Cancer. Journal International Du Cancer·Min-Kyung ChooIkuo Saiki
Apr 16, 2016·Molecular Medicine Reports·Changying LiuBo Li
Oct 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yu WuNaofumi Mukaida
Oct 2, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ningfei GuoHaitao Shen
May 1, 2021·Cancers·Ekaterina O GubernatorovaSergei A Nedospasov

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