Spontaneous Regression of Methotrexate-related Lymphoproliferative Disorder with T-cell Large Granular Lymphocytosis

Internal Medicine
Hiroshi UreshinoShinya Kimura

Abstract

Spontaneous regression of methotrexate-related lymphoproliferative disorders (MTX-LPDs) occurs in some patients after withdrawal of MTX. However, the mechanisms by which MTX withdrawal contributes to the spontaneous regression of MTX-LPDs have not been fully elucidated. We herein show that spontaneous regression of MTX-LPDs is associated with the development of significant and transient T-cell large granular lymphocyte (T-LGL) lymphocytosis induced by MTX withdrawal. Since T-LGLs show strong cytotoxicity, their expansion may contribute to the spontaneous regression of lymphoma. Therefore, the development of T-LGL lymphocytosis maybe associated with a favorable prognosis in MTX-LPD patients.

References

Jun 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E SalloumJ Murren
Apr 21, 2010·International Journal of Hematology·Yasunobu NagataHisashi Sakamaki

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Citations

Mar 16, 2016·American Journal of Respiratory and Critical Care Medicine·Yosuke KamiyaTakafumi Suda

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